2,4-Benzyliden-D-xylose-diaethylmercaptal | 93157-48-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2,4-Benzyliden-D-xylose-diaethylmercaptal
• 英文别名: 2,4-O-Benzyliden-D-xylose-diaethylmercaptoacetal；O²,O⁴-((Ξ)-benzylidene)-D-xylose-diethyldithioacetal；O²,O⁴-((Ξ)-Benzyliden)-D-xylose-diaethyldithioacetal；(4R,5S,6R)-4-[bis(ethylsulfanyl)methyl]-6-(hydroxymethyl)-2-phenyl-1,3-dioxan-5-ol
• CAS: 93157-48-3
• 化学式: C₁₆H₂₄O₄S₂
• 分子量: 344.496
• InChiKey: VOZMUPPJOWINOC-PEUVFPKISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 丙酮 作用下， 生成 2,4-Benzyliden-D-xylose-diaethylmercaptal
  参考文献：
  名称：

  THE SYNTHESIS OF 3-O-β-D-XYLOPYRANOSYL-D-XYLOSE AND THE RECHARACTERIZATION OF SOME BENZYLIDENE DERIVATIVES OF D-XYLOSE

  摘要：

  D-木糖二乙基二硫缩醛的二-O,O-亚苄基衍生物中的亚苄基基团位于2,4:3,5的位置，而不是Zinner、Rembarz、Linke、Ulbricht提出的2,3:4,5的位置。部分水解得到了2,4-O-亚苄基化合物，从中制备了3-O-β-D-木吡喃糖基-D-木糖（rhodymenabiose）。

  DOI：

  10.1139/v60-184

文献信息

• Zinner et al., Chemische Berichte, 1957, vol. 90, p. 1761,1767
  作者：Zinner et al.

  DOI：——

  日期：——
• NOVEL PENTOSE DERIVATIVES AS ANTI-HYPERGLYCEMIC DRUGS
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：EP1554299B1

  公开（公告）日：2013-01-30
• [EN] NOVEL PENTOSE DERIVATIVES AS ANTI-HYPERGLYCEMIC DRUGS<br/>[FR] NOUVEAUX DERIVES DE PENTOSES UTILISES EN TANT DE MEDICAMENTS ANTI-HYPERGLYCEMIQUES
  申请人：YISSUM RES DEV CO

  公开号：WO2004034960A2

  公开（公告）日：2004-04-29

  The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.