9-Octanoyl-adenin | 64442-46-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-Octanoyl-adenin
• 英文别名: 9-octanoyl-9H-purin-6-ylamine；1-(6-Aminopurin-9-yl)octan-1-one
• CAS: 64442-46-2
• 化学式: C₁₃H₁₉N₅O
• 分子量: 261.327
• InChiKey: WTSIQNQUJAOLHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  86.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Biocatalytic synthesis of aminodeoxy purine N9-beta-D-nucleosides containing 3-amino-3-deoxy-beta-D-ribofuranose, 3-amino-2,3-dideoxy-beta-D-ribofuranose, and 2-amino-2-deoxy-beta-D-ribofuranose as sugar moieties
  申请人：Barai N. Vladimir

  公开号：US20070065922A1

  公开（公告）日：2007-03-22

  Purine N 9 -β-D-nucleosides containing 3-amino-3-deoxy-β-D-ribofaranose, 3-amino-2,3-dideoxy-β-D-ribofuranose, and 2-amino-2-deoxy-β-D-ribofuranose as sugar moieties are synthesized by biocatalytic transglycosylation of purine bases and the respective 3′-amino-3′-deoxyuridine, 3′-amino-3′-deoxythymidine and 2′-amino-2′-deoxyuridine as donors of the carbohydrate moiety, and the cells of Escherichia coli as a biocatalyst or glutaraldehyde (GA) treated cells of Escherichia coli as a biocatalyst or a mixture of thymidine (uridine) phosphorylase and purine nucleoside phosphorylase.

  含有3-氨基-3-脱氧-β-D-核糖呋喃糖，3-氨基-2,3-二脱氧-β-D-核糖呋喃糖和2-氨基-2-脱氧-β-D-核糖呋喃糖作为糖基团的嘌呤N9-β-D-核苷酸，通过生物催化转基因嘌呤碱基和相应的3'-氨基-3'-脱氧尿苷、3'-氨基-3'-脱氧胸苷和2'-氨基-2'-脱氧尿苷作为碳水化合物基团供体，以大肠杆菌细胞作为生物催化剂或经戊二醛处理的大肠杆菌细胞作为生物催化剂或胸苷（尿苷）磷酸化酶和嘌呤核苷酸磷酸化酶的混合物进行合成。
• US4145531A
  申请人：——

  公开号：US4145531A

  公开（公告）日：1979-03-20
• [EN] METHOD FOR PREPARING 3'-AMINO-2',3'-DIDEOXYADENOSINE BY USING NUCLEOSIDE PHOSPHORYLASE DERIVED FROM BACILLUS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 3'-AMINO-2',3'-DIDÉSOXYADÉNOSINE AU MOYEN D'UNE NUCLÉOSIDE PHOSPHORYLASE DÉRIVÉE DE BACILLUS
  申请人：ST PHARM CO LTD

  公开号：WO2017164615A1

  公开（公告）日：2017-09-28

  The present invention relates to a method for preparing 3'-amino-2',3'-dideoxyadenosine using Bacillus stearothermophilus-derived nucleoside phosphorylases. According to the method of the present invention, 3'-amino-2',3'-dideoxyadenosine can be mass-produced efficiently and economically through high rate enzymatic conversion and high purity of purification.