4-isopropyl-2-(1-phenyl-3H-inden-5-yloxymethyl)-morpholine | 60929-30-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 4-isopropyl-2-(1-phenyl-3H-inden-5-yloxymethyl)-morpholine
• 英文别名: 4-isopropyl-2-(3-phenyl-6-indenyloxymethyl)morpholine；4Isopropyl-2-(3-phenyl-6-indenyloxymethyl)morpholine；2-[(1-phenyl-3H-inden-5-yl)oxymethyl]-4-propan-2-ylmorpholine
• CAS: 60929-30-8
• 化学式: C₂₃H₂₇NO₂
• 分子量: 349.473
• InChiKey: OAWKAXIXKNIVTF-UHFFFAOYSA-N

物化性质

• 沸点：
  486.6±45.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(1-Hydroxy-1-phenyl-5-indanyloxymethyl)-4-isopropylmorpholine 、 、 对甲苯磺酸 在 邻二甲苯 、 silica gel 、 氯仿 、 乙酸乙酯 作用下， 以 邻二甲苯 为溶剂， 反应 8.0h， 以to provide 1.0 g的产率得到4-isopropyl-2-(1-phenyl-3H-inden-5-yloxymethyl)-morpholine
  参考文献：
  名称：

  2-(Indenyloxymethyl) morpholine derivatives

  摘要：

  本文揭示了2-(Indenyloxymethyl) morpholine衍生物。这些衍生物在甲基苯丙胺立体增加和抗利血平活性方面表现出色，可作为抗抑郁剂使用。

  公开号：

  US04109088A1

文献信息

• Use of combinations comprising a corticosteroid and a pyrimidopyrimidine in the treatment of inflammatory diseases
  申请人：Combinatorx, Incorporated

  公开号：EP2070550A1

  公开（公告）日：2009-06-17

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

  本发明的特点是通过向患者单独或与一种或多种附加制剂联合使用四取代嘧啶嘧啶，治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明的另一个特点是含有四取代嘧啶嘧啶的组合物与一种或多种附加制剂的组合物。
• Methods, compositions, and kits for the treatment of ophthalmic disorders
  申请人：CombinatoRx, Inc.

  公开号：EP2218442A1

  公开（公告）日：2010-08-18

  The invention features methods, compositions and kits comprising a corticosteroid and a non-steroidal immunophilin-dependent immunosuppressant for treating an ophthalmic disorder in a patient, wherein at least one of said corticosteroid and said non-steroidal immunophilin-dependent immunosuppressant is present at a low concentration, in particular wherein said corticosteroid is prednisolone acetate and said non-steroidal immunophilin-dependent immunosuppressant is cyclosporine A.

  本发明的特征是包含皮质类固醇和非类固醇免疫嗜血素依赖性免疫抑制剂的方法、组合物和试剂盒，用于治疗患者的眼科疾病、其中，所述皮质类固醇和所述非类固醇免疫嗜血素依赖性免疫抑制剂中至少有一种以低浓度存在，特别是所述皮质类固醇为醋酸泼尼松龙，所述非类固醇免疫嗜血素依赖性免疫抑制剂为环孢素 A。
• Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
  申请人：——

  公开号：US20040229849A1

  公开（公告）日：2004-11-18

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.

  本发明的特点是通过向患者施用 SSRI 或其类似物或代谢物以及皮质类固醇或其他化合物来治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明的另一个特点是含有 SSRI 或其类似物或代谢物和皮质类固醇或其他化合物的药物组合物，用于治疗或预防免疫炎症性疾病。
• Combination therapy for the treatment of immunoinflammatory disorders
  申请人：——

  公开号：US20040224876A1

  公开（公告）日：2004-11-11

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and an NsIDI enhancer (NsIDIE) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and NsIDIE or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.

  本发明的特点是通过向患者施用非甾体类免疫嗜血素依赖性免疫抑制剂（NsIDI）和NsIDI增强剂（NsIDIE）或其类似物或代谢物来治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明还具有一种含有 NsIDI 和 NsIDIE 或其类似物或代谢物的药物组合物，用于治疗或预防免疫炎症性疾病。
• Methods and reagents for the treatment of immunoinflammatory disorders
  申请人：Keith Curtis

  公开号：US20050119160A1

  公开（公告）日：2005-06-02

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

  本发明的特点是通过向患者单独或与一种或多种附加制剂联合使用四取代嘧啶嘧啶，治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明的另一个特点是含有四取代嘧啶嘧啶的组合物与一种或多种附加制剂的组合物。