7,8-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid | 1415215-10-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: 7,8-difluoro-4H-thieno[3,2-c]thiochromene-2-carboxylic acid
• CAS: 1415215-10-9
• 化学式: C₁₂H₆F₂O₂S₂
• 分子量: 284.307
• InChiKey: UFYKHLAWFCSYSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  90.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE
  申请人：Lexicon Pharmaceuticals, Inc.

  公开号：EP2714675B1

  公开（公告）日：2019-01-02
• [EN] 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE<br/>[FR] INHIBITEUR DE PECTINE ACÉTYLESTÉRASE DE NOTUM À BASE DE 4H-THIÉNO[3,2-C]CHROMÈNE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2012166458A1

  公开（公告）日：2012-12-06

  Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
• [EN] COMBINATION OF MEK INHIBITORS AND SELECTIVE INHIBITORS OF AURORA A KINASE<br/>[FR] COMBINAISON D'INHIBITEURS DE MEK ET D'INHIBITEURS SÉLECTIFS DE KINASE AURORA A
  申请人：MILLENNIUM PHARM INC

  公开号：WO2012167247A1

  公开（公告）日：2012-12-06

  The present invention relates to methods for the treatment of proliferative disorders. In particular, the invention provides methods for treatment of proliferative disorders by administering a MEK inhibitor in combination with a selective inhibitor of Aurora A kinase.