22-methoxycarbonyl-3β,24-diacetoxycholesta-5,7-dien-25-ol | 83066-79-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 22-methoxycarbonyl-3β,24-diacetoxycholesta-5,7-dien-25-ol
• 英文别名: methyl 4-acetyloxy-2-[(1S)-1-[(3S,9S,10R,13R,14R,17R)-3-acetyloxy-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]-5-hydroxy-5-methylhexanoate
• CAS: 83066-79-9
• 化学式: C₃₃H₅₀O₇
• 分子量: 558.756
• InChiKey: TYNKCEUOZLXTMY-FPQZUYFGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  99.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  methyl 4-acetyloxy-2-[(1S)-1-[(3S,8R,9S,10R,13R,14S,17R)-3-acetyloxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]-5-hydroxy-5-methylhexanoate 、 1,3-二溴-5,5-二甲基海因 以35%的产率得到
  参考文献：
  名称：

  OSHIDA, JUN-ICHI;NISHIKAWA, OSAMU;TSURUTA, HIDEKI;TAKESHITA, TORU;YAMAMOT+

  摘要：

  DOI：

文献信息

• Vitamin D.sub.3 derivatives, process for preparation thereof, and
  申请人：Teijin Limited

  公开号：US04456553A1

  公开（公告）日：1984-06-26

  The present invention relates to novel vitamin D.sub.3 derivatives which have a carboxyl group or its ester group at the 22-position, processes for the preparation thereof, and antigens, which comprise said vitamin D.sub.3 derivative and an immunogenic carrier material, to be used for the preparation of antibodies for enzymeimmunoassay or radioimmunoassay and antibodies obtained therefrom. The determination of such activated vitamin D.sub.3 compounds as 25-hydroxy vitamin D.sub.3, 24, 25-dihydroxy vitamin D.sub.3, etc. can be made satisfactorily according to the present invention.

  本发明涉及一种新型维生素D.sub.3衍生物，其在22位点具有羧基或其酯基，以及用于制备该衍生物的方法和包括所述维生素D.sub.3衍生物和免疫原携带材料的抗原，用于制备用于酶免疫分析或放射免疫分析的抗体以及从中获得的抗体。根据本发明，可以满意地确定25-羟基维生素D.sub.3、24,25-二羟基维生素D.sub.3等活化维生素D.sub.3化合物。
• Novel vitamin D3 derivatives, processes for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
  申请人：TEIJIN LIMITED

  公开号：EP0092004A1

  公开（公告）日：1983-10-26

  he present invention relates to novel vitamin D3 derivatives which have a carboxyl group or its ester group at the 22-position, processes for the preparation thereof, and antigens, which comprise said vitamin D3 derivative and an immunogenic carrier material, to be used for the preparation of antibodies for enzymeimmunoassay or radioimmunoassay and antibodies obtained therefrom. The determination of such activated vitamin D3 compounds as 25-hydroxy vitamin D3, 24,25-dihydroxy vitamin D., etc. can be made satisfactorily according to the present invention.

  本发明涉及在 22 位上有羧基或其酯基的新型维生素 D3 衍生物、其制备工艺、以及由上述维生素 D3 衍生物和免疫原载体材料组成的抗原，用于制备酶免疫测定或放射免疫测定的抗体以及由此获得的抗体。 根据本发明，可以令人满意地测定 25-羟基维生素 D3、24,25-二羟基维生素 D 等活化维生素 D3 化合物。
• US4456553A
  申请人：——

  公开号：US4456553A

  公开（公告）日：1984-06-26