[(S)-1-((R)-4-tert-Butoxycarbonylamino-6-oxo-tetrahydro-pyran-2-ylmethyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester | 604003-37-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [(S)-1-((R)-4-tert-Butoxycarbonylamino-6-oxo-tetrahydro-pyran-2-ylmethyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester
• CAS: 604003-37-4
• 化学式: C₂₀H₃₅N₃O₆
• 分子量: 413.514
• InChiKey: GUPNEAWGMFXXKO-SNTRVMSOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  29.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  106.2
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  [(S)-1-((R)-4-tert-Butoxycarbonylamino-6-oxo-tetrahydro-pyran-2-ylmethyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 在 lithium hydroxide 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 (R)-3-tert-Butoxycarbonylamino-6-((S)-3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-5-hydroxy-hexanoic acid
  参考文献：
  名称：

  N- and C-terminal modifications of negamycin

  摘要：

  Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic discovery program. An orthogonally protected beta-amino acid derivative 3a was synthesized and used in parallel synthesis of negamycin derivatives on solid support. This advanced intermediate was also used for N- and C-terminal modifications using solution-phase methodologies. The N-terminal modifications have resulted in the identification of active analogues, whereas the C-terminal modifications resulted in complete loss of antibacterial activity. The N-methyl negamycin analogue, 19a, inhibits protein synthesis (IC50 = 2.3 muM), has antibacterial activity (Escherichia coli, MIC = 16 mug/mL), and is efficacious in an E. coli murine septicemia model (ED50 = 16.3 mg/kg). (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00393-7
• 作为产物：
  描述：

  Boc-(R)-3-氨基-5-己烯酸 在 碘 、 碳酸氢钠 、 potassium iodide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.5h， 生成 [(S)-1-((R)-4-tert-Butoxycarbonylamino-6-oxo-tetrahydro-pyran-2-ylmethyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  N- and C-terminal modifications of negamycin

  摘要：

  Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic discovery program. An orthogonally protected beta-amino acid derivative 3a was synthesized and used in parallel synthesis of negamycin derivatives on solid support. This advanced intermediate was also used for N- and C-terminal modifications using solution-phase methodologies. The N-terminal modifications have resulted in the identification of active analogues, whereas the C-terminal modifications resulted in complete loss of antibacterial activity. The N-methyl negamycin analogue, 19a, inhibits protein synthesis (IC50 = 2.3 muM), has antibacterial activity (Escherichia coli, MIC = 16 mug/mL), and is efficacious in an E. coli murine septicemia model (ED50 = 16.3 mg/kg). (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00393-7