methyl 4-hydroxybenzenecarbothioate | 119540-61-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: methyl 4-hydroxybenzenecarbothioate
• 英文别名: O-methyl 4-hydroxybenzenecarbothioate
• CAS: 119540-61-3
• 化学式: C₈H₈O₂S
• 分子量: 168.216
• InChiKey: DWIBUYBTRPMQBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯甲酸甲酯 在 tetraphosphorus decasulfide 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 12.0h， 以15%的产率得到methyl 4-hydroxybenzenecarbothioate
  参考文献：
  名称：

  P4S10/dimethicone tandem: efficient reagent for thionation of various aromatic amides and esters

  摘要：

  Organosulfur compounds are valuable because of their rich and varied chemistry especially in biological field. We report a new and efficient way for thionation of various aromatic amides and esters using P4S10/dimethicone tandem. The ease of handling and higher yield makes this protocol economical. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.05.100

文献信息

• Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides
  申请人：——

  公开号：US20030144502A1

  公开（公告）日：2003-07-31

  A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2′, C3′, C4′ and/or C5′ position. Particularly contemplated compounds also include prodrug forms of the purine nucleoside analogs, and both purine nucleoside analogs and the corresponding prodrugs are employed in the reduction of growth of neoplastic cells.

  一种嘌呤核苷类似物包括吡啶并［2,3-d］嘧啶或嘧啶并［4,5-d］嘧啶，进一步具有一个糖基团，在C2′、C3′、C4′和/或C5′位置可以选择性地被修饰。特别考虑的化合物还包括嘌呤核苷类似物的前药形式，嘌呤核苷类似物和相应的前药都用于抑制肿瘤细胞的生长。
• PYRIDO[2,3-D]PYRIMIDINE AND PYRIMIDO[4,5-D]PYRIMIDINE NUCLEOSIDES
  申请人：Ribapharm, Inc.

  公开号：EP1303282A1

  公开（公告）日：2003-04-23
• EP1303282A4
  申请人：——

  公开号：EP1303282A4

  公开（公告）日：2004-04-07
• US7081449B2
  申请人：——

  公开号：US7081449B2

  公开（公告）日：2006-07-25
• [EN] PYRIDO[2,3-D]PYRIMIDINE AND PYRIMIDO[4,5-D]PYRIMIDINE NUCLEOSIDES<br/>[FR] NUCLEOSIDES DE PYRIDO[2,3-D]PYRIMIDINE ET DE PYRIMIDO[4,5-D]PYRIMIDINE
  申请人：ICN PHARMACEUTICALS

  公开号：WO2002003997A1

  公开（公告）日：2002-01-17

  A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2', C3', C4' and/or C5' position. Particularly contemplated compounds also include prodrug forms of the purine nucleoside analogs, and both purine nucleoside analogs and the corresponding prodrugs are employed in the reduction of growth of neoplastic cells.