1-Decanaminium, N,N,N-triethyl-, chloride | 38443-60-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Decanaminium, N,N,N-triethyl-, chloride
• 英文别名: decyl(triethyl)azanium;chloride
• CAS: 38443-60-6
• 化学式: C16H36ClN
• 分子量: 277.9
• InChiKey: CDJGWBCMWHSUHR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• FLUORESCENCE DETECTION OF POISON OAK OIL
  申请人：The Regents of the University of California

  公开号：US20130121924A1

  公开（公告）日：2013-05-16

  The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.

  本公开的发明提供了用于合成所述组合物的方法，以及使用所述组合物的方法，其中这些组合物和方法可用于结合和/或使毒橡树油（如漆酚）失活。这些组合物和方法可用于治疗和/或减轻对毒橡树、毒藤、毒漆树、芒果、漆树和腰果中发现的天然化合物的炎症反应和/或过敏反应。
• COMPOSITIONS COMPRISING LIPOXYGENASE INHIBITORS AND CYCLODEXTRIN
  申请人：Kipp E. James

  公开号：US20070111965A1

  公开（公告）日：2007-05-17

  The present invention is directed to formulations of inclusion complexes of lipoxygenase inhibitors and cyclodextrins having a therapeutically effective concentration of the lipoxygenase inhibitor, methods of making the same and methods of treating disease states using the same. Forming cyclodextrin complexes permits the enhancement of the aqueous solubility of lipoxygenase inhibitors which allows higher concentrations of the lipoxygenase in solution. Aqueous formulations of lipoxygenase inhibitors-cyclodextrin complexes are suitable for parenteral or oral administration for treating and/or preventing inflammatory disease states. The aqueous formulations can be lyophilized to prolong storage stability, assist in oral administration and/or provide for convenient and economical packaging.

  本发明涉及含脂氧化酶抑制剂和环糊精的包含物复合物的配方，具有治疗有效浓度的脂氧化酶抑制剂，制备方法以及使用它们治疗疾病状态的方法。形成环糊精复合物可以增强脂氧化酶抑制剂的水溶性，从而允许在溶液中获得更高浓度的脂氧化酶。脂氧化酶抑制剂-环糊精复合物的水溶性配方适用于静脉或口服给药，用于治疗和/或预防炎症性疾病状态。水溶性配方可以冻干以延长储存稳定性，帮助口服给药和/或提供方便和经济的包装。
• COMPOSITIONS OF LIPOXYGENASE INHIBITORS
  申请人：Kipp E. James

  公开号：US20070134341A1

  公开（公告）日：2007-06-14

  Pharmaceutical compositions comprising particles of lipoxygenase inhibitor compounds having an effective average size of from about 10 nm to about 50 microns are provided. More particularly, pharmaceutical compositions of particle of a 5-lipoxygenase inhibitor compound having an effective average size of from about 50 nm to about 5 microns are provided. The pharmaceutical compositions are in the form of aqueous suspensions with the particle of the 5-lipoxygenase inhibitor compound present in concentrations of from about 5 to about 200 mg/ml. In addition, methods for making such pharmaceutical compositions are provided. In particular, microprecipitation and direct homogenization in the presence of at least one surfactant are disclosed for making the pharmaceutical compositions.

  提供了包含脂氧合酶抑制剂化合物颗粒的制药组合物，其有效平均尺寸从大约10纳米到大约50微米。更具体地，提供了有效平均尺寸从大约50纳米到大约5微米的5-脂氧合酶抑制剂化合物颗粒的制药组合物。这些制药组合物以水悬浮液的形式存在，其中5-脂氧合酶抑制剂化合物的颗粒浓度为大约5到200毫克/毫升。此外，还提供了制备这种制药组合物的方法。具体来说，揭示了使用至少一种表面活性剂进行微相沉淀和直接均质化制备制药组合物的方法。
• Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use
  申请人：Babul Najib

  公开号：US20120065221A1

  公开（公告）日：2012-03-15

  The present invention is directed to oral, therapeutically effective extended release pharmaceutical compositions of 3-hydroxy-N-methylmorphinan, including delayed onset, extended release dosage forms and the use thereof.

  本发明涉及口服、治疗有效的3-羟基-N-甲基吗啡酮的延迟作用、延长释放药物组成物，包括延迟起效、延长释放剂型及其使用。
• Detergent compositions with high activity cellulase and quaternary ammonium compounds
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0495554A1

  公开（公告）日：1992-07-22

  The present invention provides a detergent composition comprising a quaternary ammonium compound of formula         R₁R₂R₃R₄N⁺ X⁻ wherein R₁ is C₈-C₁₆ alkyl, each of R₂, R₃ and R₄ is independently C₁-C₄ alkyl or hydroxy alkyl, benzyl, or - (C₂H₄₀)xH where x has a value from 2 to 5, not more than one of R₂, R₃ or R₄ being benzyl, and X is an anion, and a cellulase characterized in that said cellulase provides at least 10% removal of immobilized radio-active labelled carboxymethylcellulose according to the C14 CMC-method at 25 x 10⁻⁶% by weight of cellulase protein in the laundry test solution. According to the present invention, a preferred cellulase consists of a homogeneous endoglucanase component which is immunoreactive with a monoclonal antibody raised against a partially purified = 43 kD cellulase derived from Humicola insolens DM 1800.

  本发明提供了一种洗涤剂组合物，该组合物包含一种式如下的季铵盐化合物 R₁R₂R₃R₄N⁺ X- 其中 R₁ 是 C₈-C₁₆ 烷基，R₂、R₃ 和 R₄ 各自独立地是 C₁-C₄ 烷基或羟基烷基、苄基、或-(C₂H₄₀)xH 其中 x 的值为 2 至 5，R₂、R₃ 或 R₄ 中不多于一个为苄基，且 X 为阴离子、和一种纤维素酶，其特征在于，根据 C14 CMC 法，在洗衣测试溶液中纤维素酶蛋白的重量百分比为 25 x 10-⁶%时，所述纤维素酶对固定化放射性标记的羧甲基纤维素的去除率至少为 10%。 根据本发明，优选的纤维素酶由均匀的内切葡聚糖酶成分组成，该成分对部分纯化的 = 43 kD 纤维素酶具有免疫活性，该纤维素酶来自 Humicola insolens DM 1800。