2-(2,6-dichloro-phenylamino)-3H-benzimidazole-5-carboxylic acid (1,2,3,4-tetrahydro-naphthalen-2-yl)-amide | 1219119-94-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-(2,6-dichloro-phenylamino)-3H-benzimidazole-5-carboxylic acid (1,2,3,4-tetrahydro-naphthalen-2-yl)-amide
• 英文别名: 2-(2,6-dichloroanilino)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-3H-benzimidazole-5-carboxamide
• CAS: 1219119-94-4
• 化学式: C₂₄H₂₀Cl₂N₄O
• 分子量: 451.355
• InChiKey: GABJRVZRZMUJFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  69.8
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS<br/>[FR] 1H-BENZIMIDAZOLE-5-CARBOXAMIDES COMME AGENTS ANTI-INFLAMMATOIRES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010034796A1

  公开（公告）日：2010-04-01

  There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.

  提供了具有式（I）的化合物，其中R1、R6、R8、Q2、Q3、Q3a、Q4、L和A的含义如描述中所给，并且其药学上可接受的盐，这些化合物在治疗需要或期望抑制MAPEG家族成员活性的疾病方面是有用的，特别是在炎症和/或癌症的治疗中。
• 1H-Benz Imidazole-5-Carboxamides As Anti-Inflammatory Agents
  申请人：Pfau Roland

  公开号：US20110312935A1

  公开（公告）日：2011-12-22

  There are provided compounds of formula (I), wherein R 1 , R 6 , R 8 , Q 2 , Q 3 , Q 3a , Q 4 , L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer.

  提供了式（I）的化合物，其中R1，R6，R8，Q2，Q3，Q3a，Q4，L和A的含义如描述中所述，并且其药学上可接受的盐。这些化合物在治疗需要抑制MAPEG家族成员活性的疾病，尤其是在治疗炎症和/或癌症方面非常有用。
• 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2334652A1

  公开（公告）日：2011-06-22
• US8916599B2
  申请人：——

  公开号：US8916599B2

  公开（公告）日：2014-12-23