9-Ethylisoguanine | 7674-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-Ethylisoguanine
• 英文别名: 6-amino-9-ethyl-3,9-dihydro-purin-2-one；6-amino-9-ethyl-1H-purin-2-one
• CAS: 7674-30-8
• 化学式: C₇H₉N₅O
• 分子量: 179.181
• InChiKey: WAROSONKWRJRIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  83.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• SEQUENCE SPECIFIC DOUBLE-STRANDED DNA/RNA BINDING COMPOUNDS AND USES THEREOF
  申请人：RAYAN ANWAR

  公开号：US20100284959A1

  公开（公告）日：2010-11-11

  The present invention provides specific double-stranded DNA/RNA binding compounds having a polymeric structure, which are in fact, triplex forming molecules capable of binding tightly and specifically to predetermined sequences in the major groove of double stranded nucleic acid molecules; as well as pharmaceutical compositions comprising thereof. The triplex forming molecules and the pharmaceutical compositions of the invention can be used for various therapeutic applications such as site-specific modulation of gene expression and targeting of DNA or RNA damage, as well as for diagnostic applications in vitro.

  本发明提供了具有聚合结构的特定双链DNA / RNA结合化合物，实际上是三链形成分子，能够紧密而特异地结合到双链核酸分子的主沟槽中的预定序列；以及包括它们的制药组合物。本发明的三链形成分子和制药组合物可用于各种治疗应用，例如位点特异性基因表达调节和DNA或RNA损伤的靶向，以及体外诊断应用。
• 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
  申请人：INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.

  公开号：US11203610B2

  公开（公告）日：2021-12-21

  The present disclosure relates to 2′3′ cyclic phosphonate dinucleotides of general formula (J), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.

  本公开涉及通式(J)的2′3′环膦酸二核苷酸、它们的药学上可接受的盐、它们的药物组合物和所述物质与其他药物或药品的组合物。本公开还涉及上述化合物用于治疗或预防可通过 STING 蛋白调节而改变的疾病或病症，如癌症或病毒性、过敏性和炎症性疾病。此外，这些物质还可用作疫苗佐剂。