(6aR,8R,9R,9aR)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl (6-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexyl)carbamate | 1163725-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (6aR,8R,9R,9aR)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl (6-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexyl)carbamate
• CAS: 1163725-71-0
• 化学式: C₄₀H₆₃N₅O₁₀SSi₂
• 分子量: 862.205
• InChiKey: KJHQGWJXZOQKQG-BGJFKGBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.24
• 重原子数：
  58.0
• 可旋转键数：
  16.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  179.52
• 氢给体数：
  3.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  (6aR,8R,9R,9aR)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl (6-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexyl)carbamate 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以95%的产率得到
  参考文献：
  名称：

  A probe for detection of G-rich target strands through fluorescence quenching

  摘要：

  A modified fluorescent probe U(F)AA AAT CTC CGC CGC was synthesized using the nucleoside analogue 3'-O-(N,N'-diisopropylamino-2-cyanoethoxyphosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(dansyl-1-sulfonamidohexylaminocarbonyl)uridine for hybridization studies with perfectly matched (U/A) complementary DNA and with a DNA strand having similar G-rich telomeric units at their 3'-ends. Data on the thermal stability and decrease in fluorescence intensity due to the presence of dG units clearly demonstrated the potential application of this approach in DNA diagnostics in homogeneous hybridization assays.

  DOI：

  10.1134/s1068162009010087
• 作为产物：
  描述：

  N-(6-氨基己基)-5-二甲基氨基萘-1-磺酰胺 、 2'-O-(imidazol-1-ylcarbonyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)uridine 以 二氯甲烷 为溶剂， 以94%的产率得到(6aR,8R,9R,9aR)-8-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-yl (6-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexyl)carbamate
  参考文献：
  名称：

  A probe for detection of G-rich target strands through fluorescence quenching

  摘要：

  A modified fluorescent probe U(F)AA AAT CTC CGC CGC was synthesized using the nucleoside analogue 3'-O-(N,N'-diisopropylamino-2-cyanoethoxyphosphinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-O-(dansyl-1-sulfonamidohexylaminocarbonyl)uridine for hybridization studies with perfectly matched (U/A) complementary DNA and with a DNA strand having similar G-rich telomeric units at their 3'-ends. Data on the thermal stability and decrease in fluorescence intensity due to the presence of dG units clearly demonstrated the potential application of this approach in DNA diagnostics in homogeneous hybridization assays.

  DOI：

  10.1134/s1068162009010087