N-(4-Chlorobenzyl)-2-(4-morpholinylmethyl)-4-thioxo-7-[2-(1-pyrrolidinyl)ethyl]-4,7-dihydrothieno[2,3-b]pyridine-5-carbothioamide | 501424-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(4-Chlorobenzyl)-2-(4-morpholinylmethyl)-4-thioxo-7-[2-(1-pyrrolidinyl)ethyl]-4,7-dihydrothieno[2,3-b]pyridine-5-carbothioamide
• 英文别名: N-[(4-chlorophenyl)methyl]-2-(morpholin-4-ylmethyl)-7-(2-pyrrolidin-1-ylethyl)-4-sulfanylidenethieno[2,3-b]pyridine-5-carbothioamide
• CAS: 501424-53-9
• 化学式: C₂₆H₃₁ClN₄OS₃
• 分子量: 547.209
• InChiKey: CUOAUCQFWRUWGG-UHFFFAOYSA-N

物化性质

• 沸点：
  664.2±65.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 4-Thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents
  申请人：——

  公开号：US20030100536A1

  公开（公告）日：2003-05-29

  The invention provides a compound of formula I: 1 wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection, atherosclerosis or restenosis using such compounds or salts.

  该发明提供了式I的化合物：1其中R1、R2、R3和R4具有规范中定义的任何值，或其药学上可接受的盐，以及用于制备这种化合物或盐的中间体和过程，以及使用这种化合物或盐治疗疱疹病毒感染、动脉粥样硬化或再狭窄的方法。
• 4-THIOXO-4,7-DIHYDRO-THIENO 2,3-B]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1421088A1

  公开（公告）日：2004-05-26
• US6924283B2
  申请人：——

  公开号：US6924283B2

  公开（公告）日：2005-08-02
• [EN] 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS<br/>[FR] AGENTS ANTIVIRAUX A BASE DE 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOTHIOAMIDES
  申请人：UPJOHN CO

  公开号：WO2003020728A1

  公开（公告）日：2003-03-13

  The invention provides a compound of Formula (I); wherein R?1, R2, R3, and R4¿ have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpesvirus infection using such compounds or salts.
• [EN] 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS<br/>[FR] 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOTHIOAMIDES EN TANT QU'AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2003020730A1

  公开（公告）日：2003-03-13

  The invention provides a compound of formula (I): wherein R?1, R2, R3, and R4¿ have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection, atherosclerosis or restenosis using such compounds or salts.