sodium 2,3-bis(hexadecyloxy)propyl-12-methacryloyl-3,6,9,12-tetraoxadodecylphosphate | 96326-73-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: sodium 2,3-bis(hexadecyloxy)propyl-12-methacryloyl-3,6,9,12-tetraoxadodecylphosphate
• 英文别名: Sodium;2,3-dihexadecoxypropyl 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl phosphate
• CAS: 96326-73-7
• 化学式: C₄₇H₉₂O₁₁P*Na
• 分子量: 887.204
• InChiKey: NERLCIJNVPCVOP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  9.03
• 重原子数：
  60
• 可旋转键数：
  51
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  131
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  三缩四乙二醇 在 4-二甲氨基吡啶 、 sodium hydroxide 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.25h， 生成 sodium 2,3-bis(hexadecyloxy)propyl-12-methacryloyl-3,6,9,12-tetraoxadodecylphosphate
  参考文献：
  名称：

  可聚合脂质中的亲水间隔基团：从本体聚合脂质形成生物膜模型

  摘要：

  制备 d'une serie delipides 可聚合成分 un groupe d'espacement Hydrophile entre le groupe reactif et la structure amphiphile principale。Etude des coches monomoleculaires, des liposomes et des coches multimoleculaires forees a partir de ces composes

  DOI：

  10.1021/ja00300a007

文献信息

• NANOLIPOPROTEIN PARTICLES AND RELATED COMPOSITIONS METHODS AND SYSTEMS FOR IMPROVED DRUG LOADING
  申请人：Lawrence Livermore National Security, LLC

  公开号：EP3426304A1

  公开（公告）日：2019-01-16
• STABLE NANOLIPOPROTEIN PARTICLES AND RELATED COMPOSITIONS METHODS AND SYSTEMS
  申请人：LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

  公开号：US20190142752A1

  公开（公告）日：2019-05-16

  Nanolipoprotein particles having at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described. The membrane lipid component includes at least one or more membrane forming lipids, one or more polymerized lipids and/or one or more polymerizable lipids.
• [EN] STABLE NANOLIPOPROTEIN PARTICLES AND RELATED COMPOSITIONS METHODS AND SYSTEMS<br/>[FR] PARTICULES DE NANOLIPOPROTÉINE STABLES, COMPOSITIONS, PROCÉDÉS ET SYSTÈMES ASSOCIÉS
  申请人：L LIVERMORE NAT SECURITY LLC

  公开号：WO2017035326A1

  公开（公告）日：2017-03-02

  Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems, in which the membrane lipid component comprises at least one or more membrane forming lipids, one ore more polymerized and/or one or more polymerizable lipids.
• [EN] NANOLIPOPROTEIN PARTICLES AND RELATED COMPOSITIONS METHODS AND SYSTEMS FOR IMPROVED DRUG LOADING<br/>[FR] PARTICULES DE NANOLIPOPROTÉINE AINSI QUE COMPOSITIONS, PROCÉDÉS ET SYSTÈMES ASSOCIÉS POUR CHARGEMENT AMÉLIORÉ DE MÉDICAMENT
  申请人：L LIVERMORE NAT SECURITY LLC

  公开号：WO2017155837A1

  公开（公告）日：2017-09-14

  Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more lysolipids.