7-iodo-7-deazaguanine | 163622-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 7-iodo-7-deazaguanine
• 英文别名: 2-Amino-5-iodo-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one；2-amino-5-iodo-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one
• CAS: 163622-51-3
• 化学式: C₆H₅IN₄O
• 分子量: 276.036
• InChiKey: CFKGELUCXJPDFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-氨基丙腈 、 一氧化碳 、 7-iodo-7-deazaguanine 在 bis-triphenylphosphine-palladium(II) chloride 作用下， 生成 cyanoethyl deazaguanine
  参考文献：
  名称：

  Synthesis and Inhibitory Activity Against Phosphatidylinositol 4-Kinase of Echiguanine Analogs

  摘要：

  N-Substituted-2-amino-4(3H)-7H-oxopyrrolo[2,3-d]pyrimidine-5-carboxamides and their ribofuranosyl and 2',3'-dideoxyribofuranosyl derivatives were prepared as membrane permeable echiguanine analogs and tested for their ability to inhibit phosphatidylinositol (PI) 4-kinase. The ethylamide 5 and the corresponding ribofuranosyl compound 11 inhibited PI 4-kinase with IC50 values of 0.02 and 2.4 mu g/ml, respectively.

  DOI：

  10.1080/15257779908041550

文献信息

• Modified nucleotides for polynucleotide sequencing
  申请人：Illumina Cambridge Limited

  公开号：EP2607369A1

  公开（公告）日：2013-06-26

  The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3'-OH blocking group covalently attached thereto, such that the 3' carbon atom has attached a group of the structure         -O-Z wherein Z is any of -C(R')2-O-R", -C(R')2-N(R")2,-C(R')2-N(H)R", -C(R')2-S-R" and -C(R')2-F, wherein each R" is or is part of a removable protecting group; each R' is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R')2 represents an alkylidene group of formula =C(R"')2 wherein each R''' may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R" is exchanged for H or, where Z is -C(R')2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3'OH; with the proviso that where Z is -C(R')2-S-R", both R' groups are not H.

  本发明提供了修饰的核苷酸或核苷分子，该分子包含一个嘌呤或嘧啶碱基和一个核糖或脱氧核糖糖基，核糖或脱氧核糖糖基上共价连接有一个可移动的 3'-OH 封闭基团，从而使 3'碳原子上连接有一个结构如下的基团 -O-Z 其中 Z 是-C(R')2-O-R"、-C(R')2-N(R")2、-C(R')2-N(H)R"、-C(R')2-S-R "和-C(R')2-F 中的任意一个 其中每个 R "是可拆卸保护基团的一部分； 每个 R'独立地为氢原子、烷基、取代烷基、芳烷基、烯基、炔基、芳基、杂芳基、杂环基、酰基、氰基、烷氧基、芳氧基、杂芳氧基或氨基，或通过连接基团连接的可检测标签；或 (R')2 代表式 =C(R"')2的亚烷基，其中每个 R''可以相同或不同，并选自包括氢原子、卤素原子和烷基在内的基团；及 其中，所述分子可通过反应生成一种中间体，在该中间体中，每个 R "被交换为 H，或者，当 Z 为-C(R')2-F 时，F 被交换为 OH、SH 或 NH2，优选 OH，该中间体在水性条件下解离，生成具有游离 3'OH 的分子； 但在 Z 为-C(R')2-S-R "的情况下，两个 R'基团都不是 H。
• [EN] BIFUNCTIONAL FOLATE RECEPTOR BINDING COMPOUNDS<br/>[FR] COMPOSÉS BIFONCTIONNELS DE LIAISON AU RÉCEPTEUR DES FOLATES
  申请人：[en]LYCIA THERAPEUTICS, INC.

  公开号：WO2022150721A1

  公开（公告）日：2022-07-14

  The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.
• WO2022272307A1
  申请人：——

  公开号：WO2022272307A1

  公开（公告）日：2022-12-29