N-(2-{4-[2-butyl-4-chloro-5-(4-phenyl-butylcarbamoyl)imidazol-1-ylmethyl]-benzenesulfonylamino}-2-oxoethyl)-N'-hydroxy-2-isobutylmalonamide | 1192346-60-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-{4-[2-butyl-4-chloro-5-(4-phenyl-butylcarbamoyl)imidazol-1-ylmethyl]-benzenesulfonylamino}-2-oxoethyl)-N'-hydroxy-2-isobutylmalonamide
• 英文别名: N-[2-[[4-[[2-butyl-4-chloro-5-(4-phenylbutylcarbamoyl)imidazol-1-yl]methyl]phenyl]sulfonylamino]-2-oxoethyl]-N'-hydroxy-2-(2-methylpropyl)propanediamide
• CAS: 1192346-60-3
• 化学式: C₃₄H₄₅ClN₆O₇S
• 分子量: 717.286
• InChiKey: LRXAOUJOICNEJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  49
• 可旋转键数：
  19
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  197
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• DUAL-ACTING ANTIHYPERTENSIVE AGENTS
  申请人：Allegretti Paul

  公开号：US20090270473A1

  公开（公告）日：2009-10-29

  The invention relates to compounds having the formula: wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT 1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

  这项发明涉及具有以下式的化合物：其中：Q、W、Y、Z、r 和 Ar 如规范中所定义，并其药学上可接受的盐。这些化合物具有AT1受体拮抗活性和酶抑制活性。该发明还涉及包含这些化合物的药物组合物；使用这些化合物的方法；以及制备这些化合物的过程和中间体。
• US7989484B2
  申请人：——

  公开号：US7989484B2

  公开（公告）日：2011-08-02
• US8227497B2
  申请人：——

  公开号：US8227497B2

  公开（公告）日：2012-07-24
• US8501798B2
  申请人：——

  公开号：US8501798B2

  公开（公告）日：2013-08-06
• [EN] DUAL-ACTING ANTIHYPERTENSIVE AGENTS<br/>[FR] AGENTS ANTIHYPERTENSEURS À DOUBLE ACTION
  申请人：THERAVANCE INC

  公开号：WO2009134741A1

  公开（公告）日：2009-11-05

  The invention relates to compounds having the formula: (I) wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.