[2-(2,3-dichloro-phenylsulfanyl)-quinazolin-4-yl]-(5-methyl-1H-pyrazol-3-yl)-amine | 438203-64-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [2-(2,3-dichloro-phenylsulfanyl)-quinazolin-4-yl]-(5-methyl-1H-pyrazol-3-yl)-amine
• 英文别名: 2-(2,3-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine；2-(2,3-dichlorophenyl)sulfanyl-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine
• CAS: 438203-64-6
• 化学式: C₁₈H₁₃Cl₂N₅S
• 分子量: 402.307
• InChiKey: PEPCSEJJADXCRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Pyrazole compounds useful as protein kinase inhibitors
  申请人：——

  公开号：US20030078275A1

  公开（公告）日：2003-04-24

  This invention describes novel pyrazole compounds of formula IIa: 1 wherein R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R x and R y are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R 2 and R 2 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

  本发明描述了公式IIa的新型吡唑化合物：1其中R1为T-Ring D，其中环D为5-7个成员的单环或8-10个成员的双环，选择自芳基，杂芳基，杂环基或碳环基；Rx和Ry一起取其介于原子形成融合的，不饱和或部分不饱和的5-7成员环，其中含有0-3个杂原子；R2和R2如说明书中所述。该化合物可用作蛋白激酶抑制剂，特别是作为Aurora-2和GSK-3的抑制剂，用于治疗癌症，糖尿病和阿尔茨海默病等疾病。
• PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS
  申请人：Bebbington David

  公开号：US20090312543A1

  公开（公告）日：2009-12-17

  This invention describes novel pyrazole compounds of formula IIIa: wherein R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R x , R y , R 2 , and R 2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

  本发明描述了式IIIa的新型吡唑化合物： 其中R1是T-Ring D，其中环D是5-7成员单环或8-10成员双环，选自芳基，杂芳基，杂环基或碳环基；Rx，Ry，R2和R2'如说明书所述。该化合物可用作蛋白激酶抑制剂，特别是用于抑制Aurora-2和GSK-3，治疗癌症，糖尿病和阿尔茨海默病等疾病。
• US6653301B2
  申请人：——

  公开号：US6653301B2

  公开（公告）日：2003-11-25
• US7531536B2
  申请人：——

  公开号：US7531536B2

  公开（公告）日：2009-05-12
• US7625913B2
  申请人：——

  公开号：US7625913B2

  公开（公告）日：2009-12-01