2,8-dichlor-6-benzylamino-purin | 78295-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2,8-dichlor-6-benzylamino-purin
• 英文别名: benzyl-(2,8-dichloro-7(9)H-purin-6-yl)-amine；N-benzyl-2,8-dichloro-7H-purin-6-amine
• CAS: 78295-86-0
• 化学式: C₁₂H₉Cl₂N₅
• 分子量: 294.143
• InChiKey: DVRWNGWMWQVFPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof
  申请人：USTAV EXPERIMENTALNI BOTANIKY AV CR

  公开号：US20030191086A1

  公开（公告）日：2003-10-09

  Various substituted nitrogen heterocyclic derivatives and their pharmaceutically acceptable salt derivatives are provided for use as medicaments, and particularly, as antimitotic, anti-viral, anti-cancer, anti-degenerative, immunosuppressive, and anti-microbial drugs or, vaccines. These heterocyclic derivatives can be used as an active agent in a pharmaceutical, as well as a diagnostic utility. To this end, several families of heterocyclic derivatives are provided including pyrrolopyrimidines, pyrazolopyrimidines, purines, and imidazopyridines. In particular, certain tri-substituted and tetra-substituted purines and pyrazolopyrimidines and their deaza analogues are provided for inhibiting cyclin-dependent kinase (“cdk”) proteins, viruses, and immunostimulation.

  提供了各种取代的氮杂环衍生物及其药学上可接受的盐衍生物，用作药物，特别是作为抗有丝分裂、抗病毒、抗癌、抗变性、免疫抑制和抗微生物药物或疫苗。这些杂环衍生物可以用作药物的活性成分，也可以用作诊断工具。为此，提供了几个杂环衍生物家族，包括吡咯吡咯嘧啶、吡唑嘧啶、嘌呤和咪唑吡啶。特别地，提供了某些三取代和四取代的嘌呤和吡唑嘧啶及其去氮类似物，用于抑制细胞周期依赖性激酶（“cdk”）蛋白、病毒和免疫刺激。
• SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF
  申请人：Ustav Experimentalni Botaniky Akademie ved Ceské Republiky

  公开号：EP1147108A1

  公开（公告）日：2001-10-24
• US6552192B1
  申请人：——

  公开号：US6552192B1

  公开（公告）日：2003-04-22
• [EN] SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF<br/>[FR] DERIVES HETEROCYCLIQUES D'AZOTE SUBSTITUE ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：USTAV EX BOTAN AKADEMIE VED CE

  公开号：WO2000043394A1

  公开（公告）日：2000-07-27

  This invention relates to new substituted nitrogen heterocyclic derivatives having cytostatic, anticancer, antimitotic, antineurogenerative, immunosuppressive and antimicrobial effects. This invention also relates to the methods for preparation of these derivatives, the use of the compounds as drugs, the pharmaceutical composition and combined pharmaceutical application form comprising an effective dose of a claimed compound and the use of these derivatives for drug production.