2,2'-methylenebis(2-methyl-2,3-dihydroquinazolin-4(1H)-one) | 1434081-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,2'-methylenebis(2-methyl-2,3-dihydroquinazolin-4(1H)-one)
• CAS: 1434081-55-6
• 化学式: C₁₉H₂₀N₄O₂
• 分子量: 336.393
• InChiKey: XQTIOWOBDNCJQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.52
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  82.26
• 氢给体数：
  4.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-氨基苯甲酰胺 、 乙酰丙酮 在 bis(glycerol)boric acid 、 bis(glycerol)boric acid 作用下， 反应 6.0h， 以78%的产率得到2,2'-methylenebis(2-methyl-2,3-dihydroquinazolin-4(1H)-one)
  参考文献：
  名称：

  Glycerol based ionic liquid with a boron core: A new highly efficient and reusable promoting medium for the synthesis of quinazolinones

  摘要：

  A highly efficient and environmental benign procedure for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones via the condensation of carbonyl compounds with 2-aminobenzamide using a glycerol based ionic liquid with a boron core as a new and reusable promoting medium is described. A broad range of substrates including aldehydes and ketone were condensed with 2-aminobenzamide. All reactions are completed in short times and the products are obtained in good to excellent yields. The reaction medium could be recycled and reused several times without any loss of efficiency. Moreover, presented procedure has been applied successfully for the synthesis of some novel bis(pyrazolinone) derivatives. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molliq.2013.01.013