2-Acetamido-4-methylpyrimidin | 1007-40-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Acetamido-4-methylpyrimidin
• 英文别名: Acetamide,n-(4-methyl-2-pyrimidinyl)-；N-(4-methylpyrimidin-2-yl)acetamide
• CAS: 1007-40-5
• 化学式: C₇H₉N₃O
• mdl: MFCD01837474
• 分子量: 151.168
• InChiKey: CUZMPWBGWFGXMO-UHFFFAOYSA-N

物化性质

• 熔点：
  148-149 °C
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Acetamido-4-methylpyrimidin 、 6-苯基-咪唑并[2,1-b]噻唑-5-甲醛 生成 N-{4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-yl}acetamide 、
  参考文献：
  名称：

  Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable

  摘要：

  Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.106
• 作为产物：
  描述：

  巴豆醛 、 N-乙酰基胍 、 氧气 以16%的产率得到
  参考文献：
  名称：

  MAMAEV V. P.; VAJS A. L., XIMIYA GETEROTSIKL. SOEDIN. , 1975, HO 11, 1555-1559

  摘要：

  DOI：

文献信息

• SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：Lyssikatos Joseph P.

  公开号：US20120322785A1

  公开（公告）日：2012-12-20

  The invention provides novel compounds having the general formula: wherein X 1 is N or N + O − , and one of X 2 , X 3 and X 4 is N or N + —O − and the remainder of X 2 , X 3 and X 4 is C. R 2 , R 3 , R 4 , R 5 , R 6 . A, B and Y are as described herein. Additionally compositions compounds of Formula I and methods of use are further described herein.

  该发明提供了新颖的化合物，其具有以下一般式：其中X1为N或N+O−，而X2、X3和X4中的一个为N或N+—O−，而X2、X3和X4的其余部分为C。R2、R3、R4、R5、R6、A、B和Y如本文所述。此外，还进一步描述了I式化合物的组合物和使用方法。
• SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
  申请人：GlaxoSmithKline Intellectual Property (No.2) Limited

  公开号：US20170355705A1

  公开（公告）日：2017-12-14

  The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
• Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
  作者：David Buttar、Mike Edge、Steve C. Emery、Martina Fitzek、Cheryl Forder、Alison Griffen、Barry Hayter、Chris F. Hayward、Philip J. Hopcroft、Richard W.A. Luke、Ken Page、John Stawpert、Andy Wright

  DOI：10.1016/j.bmcl.2008.06.106

  日期：2008.8

  Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability. (C) 2008 Elsevier Ltd. All rights reserved.
• MAMAEV V. P.; VAJS A. L., XIMIYA GETEROTSIKL. SOEDIN. <KGSS-AQ>, 1975, HO 11, 1555-1559
  作者：MAMAEV V. P.、 VAJS A. L.

  DOI：——

  日期：——