2-(2-dimethylaminoethyl)thiazole | 152483-11-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(2-dimethylaminoethyl)thiazole
• 英文别名: N,N-Dimethyl-2-thiazoleethanamine；N,N-dimethyl-2-(1,3-thiazol-2-yl)ethanamine
• CAS: 152483-11-9
• 化学式: C₇H₁₂N₂S
• 分子量: 156.252
• InChiKey: ACYMGZBEDRDLPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  44.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-羟乙基噻唑 在 氯化亚砜 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 8.5h， 生成 2-(2-dimethylaminoethyl)thiazole
  参考文献：
  名称：

  An approach to the design of brain-penetrating histaminergic agonists

  摘要：

  Known and novel histaminergic H-1- and H-2-receptor agonists were investigated as potentially potent and selective brain-penetrating compounds. Structural modifications were introduced in an attempt to favour passive diffusion across the blood-brain barrier by reducing hydrogen-bonding ability according to a previously developed model. While no novel compound was identified which satisfied our requirements for a brain-penetrating agonist, betahistine 14 and 2-(thiazol-2-yl)ethylamine 16 can be regarded as H-1-receptor agonists with moderate brain-penetrating ability, of potential value as pharmacological tools. A novel histamine analogue, N,N-bis-{2-[4(5)-imidazolyl]ethyl)amine 25 is reported which. although unlikely to be brain penetrant, was found to be equipotent with histamine at H-1- and H-1-receptors.

  DOI：

  10.1016/0223-5234(93)90135-2

文献信息

• Antiviral agents
  申请人：——

  公开号：US20040138449A1

  公开（公告）日：2004-07-15

  The invention provides a compound of formula I: 1 wherein G, R 2 , and R 3 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.

  本发明提供了一种公式I的化合物： 1 其中G，R 2 ，和R 3 具有规范中定义的任何值，或其药用可接受盐，以及用于制备该化合物或盐的有用过程和中间体，以及使用该化合物或盐治疗疱疹病毒感染的方法。
• Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging
  申请人：——

  公开号：US20020022622A1

  公开（公告）日：2002-02-21

  Provided are, among other things, compounds of formula I or IA, 1 . Also provided are methods of treatment with such compounds.

  提供的是公式I或IA,1的化合物，以及使用这些化合物进行治疗的方法。
• NOVEL HETEROCYCLIC COMPOUNDS AS PEST CONTROL AGENTS
  申请人：BAYER CROPSCIENCE AG

  公开号：US20150284380A1

  公开（公告）日：2015-10-08

  The present invention relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which also include arthropods and especially insects.

  本发明涉及新型杂环化合物，其制备方法以及用于控制动物害虫的用途，其中还包括节肢动物，特别是昆虫。
• ANTIVIRAL COMPOUNDS
  申请人：——

  公开号：US20040242884A1

  公开（公告）日：2004-12-02

  The invention provides a compound of formula I: 1 wherein G, R 2 , R 3 , and R 4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpes virus infection using such compounds or salts.

  本发明提供了一种I式化合物：1，其中G，R2，R3和R4具有规范中定义的任何值，或其药学上可接受的盐，以及用于制备这种化合物或盐的有用中间体和过程，以及使用这种化合物或盐预防或治疗疱疹病毒感染的方法。
• THIAZOLE, IMIDAZOLE AND OXAZOLE COMPOUNDS AND TREATMENTS OF DISORDERS ASSOCIATED WITH PROTEIN AGING
  申请人：Alteon, Inc.

  公开号：EP1248615A1

  公开（公告）日：2002-10-16