2-methyl-8-(4-pyridinyl)-3-[6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-imidazo[1,2-a]pyrazine | 1334167-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-methyl-8-(4-pyridinyl)-3-[6-(2,2,2-trifluoroethoxy)-3-pyridinyl]-imidazo[1,2-a]pyrazine
• 英文别名: 2-Methyl-8-pyridin-4-yl-3-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]imidazo[1,2-a]pyrazine
• CAS: 1334167-05-3
• 化学式: C₁₉H₁₄F₃N₅O
• 分子量: 385.348
• InChiKey: DAXPYXNZTDRXMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  65.2
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] IMIDAZO [1, 2 -A] PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES<br/>[FR] DÉRIVÉS D'IMIDAZO[1,2-A]PYRAZINE ET LEUR UTILISATION POUR LA PRÉVENTION OU LE TRAITEMENT DE TROUBLES ET MALADIES NEUROLOGIQUES, PSYCHIATRIQUES ET MÉTABOLIQUES.
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011110545A1

  公开（公告）日：2011-09-15

  The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.

  本发明涉及新型咪唑并[1,2-a]吡嗪衍生物，它们是磷酸二酯酶10（PDE10）的抑制剂，并且对涉及PDE10酶的神经、精神和代谢性疾病的治疗或预防具有用处。该发明还涉及包含这类化合物的药物组合物，用于制备这类化合物和组合物的方法，以及利用这类化合物或药物组合物预防或治疗神经、精神和代谢性疾病和疾病。
• IMIDAZO[1,2-a]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES
  申请人：Bartolomé-Nebreda José Manuel

  公开号：US20120329792A1

  公开（公告）日：2012-12-27

  The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.

  本发明涉及新型咪唑并[1,2-a]吡嗪衍生物，其为磷酸二酯酶10（PDE10）的抑制剂，并且适用于治疗或预防涉及PDE10酶的神经、精神和代谢性疾病。该发明还涉及包含这类化合物的药物组合物，制备这类化合物和组合物的方法，以及利用这类化合物或药物组合物预防或治疗神经、精神和代谢性疾病和疾病。
• EP2545055B1
  申请人：——

  公开号：EP2545055B1

  公开（公告）日：2017-08-09
• IMIDAZO [1, 2 -A]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2545055A1

  公开（公告）日：2013-01-16
• US8859543B2
  申请人：——

  公开号：US8859543B2

  公开（公告）日：2014-10-14