4-[1-(4-氨基苯基)-1-苯基乙基]苯胺 | 13555-38-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 中文名称: 4-[1-(4-氨基苯基)-1-苯基乙基]苯胺
• 英文名称: 4,4'-(1-phenylethane-1,1-diyl)dianiline
• 英文别名: 1.1-Bis(4-aminophenyl)-1-phenylaethan；4,4'-(1-phenylethylidene)dianiline；4-[1-(4-aminophenyl)-1-phenylethyl]aniline
• CAS: 13555-38-9
• 化学式: C₂₀H₂₀N₂
• 分子量: 288.392
• InChiKey: CJXRYVQHINFIKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[1-(4-氨基苯基)-1-苯基乙基]苯胺 在 吡啶 、 4-二甲氨基吡啶 、 potassium carbonate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 12.0h， 生成 N,N'-[(1-phenylethylidene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl)acetamide]
  参考文献：
  名称：

  Synthesis of GN8 derivatives and evaluation of their antiprion activity in TSE-infected cells

  摘要：

  A series of GN8 derivatives were synthesized from various diamines, carboxylic acid derivatives, and nitrogen nucleophiles, and their antiprion activity was tested in TSE-infected mouse neuronal cells. We found that two ethylenediamine units, hydrophobic substituents on the nitrogen atoms, and the diphenylmethane scaffold were essential structural features responsible for the activity. Seven derivatives bearing substituents at the benzylic position exhibited an improved antiprion activity with the IC50 values of 0.51-0.83 mu M. Conformational analysis of model compounds suggested that the introduction of the substituent at the benzylic position restricted the conformational variability of the diphenylmethane unit. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.132
• 作为产物：
  描述：

  aniline hydrochloride 、 苯乙酮 以26%的产率得到4-[1-(4-氨基苯基)-1-苯基乙基]苯胺
  参考文献：
  名称：

  E / Z光异构化诱导点手性

  摘要：

  照亮它：E / Z光异构化在基于偶氮苯的前手性分子中产生一个不对称中心和相应的可分离对映异构体。该不对称中心是由光诱导的中心原子上的取代基变化形成的，Z / E热异构化可再生分子中的初始对称性。不对称性的这种切换可以重复进行。

  DOI：

  10.1002/anie.201104614

文献信息

• COMPOSITION CONTAINING VINYL-GROUP-CONTAINING COMPOUND
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20160046552A1

  公开（公告）日：2016-02-18

  A composition containing a novel vinyl-group-containing compound. This composition contains a vinyl-group-containing compound represented by general formula (1). In the formula: W 1 and W 2 represent a group represented by general formula (2) (where a ring (Z) is an aromatic hydrocarbon ring, X is a single bond or —S—, R 1 is a single bond or a C1-4 alkylene group, R 2 is a specific substituent group such as a monovalent hydrocarbon, and m is an integer equal to 0 or higher), a group represented by general formula (4) (where the ring (Z), X, R 1 , R 2 , and m are as previously stated), a hydroxyl group, or a (meth)acryloyloxy group; rings (Y 1 , Y 2 ) are aromatic hydrocarbon rings; R represents a single bond or a specific divalent group; R 3a and R 3b represent a cyano group, a halogen atom, or a monovalent hydrocarbon group; and n1 and n2 are integers of 0-4.

  这个组合物包含一种含有新颖乙烯基团的化合物。该组合物包含一个由通式（1）表示的含有乙烯基团的化合物。在该式中：W1和W2代表由通式（2）表示的一个基团（其中环（Z）是芳香烃环，X是一个单键或—S—，R1是一个单键或C1-4烷基基团，R2是特定的取代基团，如一价碳氢化合物，m是大于或等于0的整数），一个由通式（4）表示的基团（其中环（Z）、X、R1、R2和m如前述），一个羟基，或一个（甲基）丙烯酰氧基团；环（Y1、Y2）是芳香烃环；R代表一个单键或一个特定的二价基团；R3a和R3b代表氰基、卤素原子或一价碳氢基团；n1和n2是0-4的整数。
• CARBONATE DERIVATIVE PRODUCTION METHOD
  申请人：NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

  公开号：US20200079723A1

  公开（公告）日：2020-03-12

  The objective of the present invention is to provide a method for producing a carbonate derivative in a safe and efficient manner. The method for producing a carbonate derivative according to the present invention is characterized in comprising irradiating light on a composition containing a C 1-4 halogenated hydrocarbon having one or more kinds of halogen atoms selected from the group consisting of a chlorine atom, a bromine atom and an iodine atom, a nucleophilic functional group-containing compound and the specific base in the presence of oxygen.

  本发明的目的是以安全高效的方式提供生产碳酸酯衍生物的方法。根据本发明的生产碳酸酯衍生物的方法的特征在于，在含有一种或多种来自氯原子、溴原子和碘原子组成的卤素原子的C1-4卤代烃、含有亲核功能基团的化合物和特定碱的组合物中，在氧气存在下照射光线。
• NOVEL (POLY)AMINE COMPOUND, RESIN AND CURED PRODUCT
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：US20200172470A1

  公开（公告）日：2020-06-04

  A (poly)amine compound represented by the following formula (0): wherein R X is a 2n A -valent group having 1 to 70 carbon atoms or a single bond; each R 1A is independently any of an alkyl group having 1 to 30 carbon atoms and optionally having a substituent, an aryl group having 6 to 30 carbon atoms and optionally having a substituent, a crosslinking group having 2 to 30 carbon atoms and optionally having a substituent, an alkoxy group having 1 to 30 carbon atoms and optionally having a substituent, a halogen atom, a nitro group, an amino group having 0 to 30 carbon atoms and optionally having a substituent, a carboxyl group, a thiol group and a hydroxy group, wherein when R 1A is any of the alkyl group, the aryl group, the crosslinking group and the alkoxy group, R 1A optionally contains at least one bond selected from the group consisting of an ether bond, a ketone bond and an ester bond, and at least one R 1A is an amino group having 0 to 30 carbon atoms and optionally having a substituent; X is an oxygen atom or a sulfur atom, or X is optionally absent; each R independently represents any of a benzene ring, a biphenyl ring, a naphthalene ring, an anthracene ring and a pyrene ring; each m is independently an integer of 0 to 9, wherein at least one m is an integer of 1 to 9; and n A is an integer of 1 to 4.

  由以下公式（0）表示的（聚）胺化合物：其中RX是一个具有1到70个碳原子或单键的2nA价基团；每个R1A独立地是1到30个碳原子的烷基基团，可选地具有取代基，含有6到30个碳原子的芳基基团，可选地具有取代基，含有2到30个碳原子的交联基团，可选地具有取代基，含有1到30个碳原子的烷氧基团，可选地具有取代基，卤原子，硝基基团，含有0到30个碳原子的氨基基团，可选地具有取代基，羧基，硫醇基和羟基，其中当R1A是烷基基团、芳基基团、交联基团和烷氧基团中的任意一种时，R1A可选地含有至少一种从醚键、酮键和酯键组成的键，至少有一个R1A是含有0到30个碳原子且可选地具有取代基的氨基基团；X是氧原子或硫原子，或X可选地不存在；每个R独立地代表苯环、联苯环、萘环、蒽环和芘环中的任意一种；每个m独立地是0到9的整数，至少有一个m是1到9的整数；nA是1到4的整数。
• BASE GENERATOR, PHOTOSENSITIVE RESIN COMPOSITION, PATTERN FORMING MATERIAL COMPRISING THE PHOTOSENSITIVE RESIN COMPOSITION, AND PATTERN FORMING METHOD AND ARTICLE USING THE PHOTOSENSITIVE RESIN COMPOSITION
  申请人：Katayama Mami

  公开号：US20110086311A1

  公开（公告）日：2011-04-14

  A photosensitive resin composition which is excellent in resolution, low in cost, and usable in a wide range of structures of polymer precursors each of which is reacted into a final product by a basic substance or by heating in the presence of a basic substance. The photosensitive resin composition includes a base generator which has a specific structure and generates a base by exposure to electromagnetic radiation and heating, and a polymer precursor which is reacted into a final product by the base generator and by a basic substance or by heating in the presence of a basic substance.

  一种光敏树脂组合物，具有分辨率优良、成本低廉和可用于一系列聚合物前体结构的特点，其中每种聚合物前体都可以通过碱性物质或在碱性物质的存在下加热反应成为最终产物。该光敏树脂组合物包括一种具有特定结构并通过电磁辐射和加热产生碱性物质的基发生剂，以及一种聚合物前体，该聚合物前体通过基发生剂和碱性物质或在碱性物质的存在下加热反应成为最终产物。
• Polyimides and polyamic acids
  申请人：——

  公开号：US20020182536A1

  公开（公告）日：2002-12-05

  A polyimide having a repeating unit of the general formula (I) and a polyamic acid having a repeating unit of the formula (IV): 1 (wherein, R 1 and R 2 represent H or a C1 to C20 alkyl group, and Z represents a condensed polycyclic aromatic group or an group of the following formulae: 2 Herein, X represents —CO— or —C(═N 2 )—, Y represents a direct bond, —CH 2 —, —O—, —SO 2 —, —S—, —CO— or —C(═N 2 )—, and W represents a direct bond, —CH 2 —, —C(CH 3 ) 2 —, —C(CF 3 ) 2 —, —S—, —SO—, —SO 2 — or —O—. b, m and n are 0 or 1; r is a C1 to 4 alkyl group, halogen group or phenyl group; a is 0 or 1 to 3.).

  具有通式(I)重复单元的聚酰亚胺和具有通式(IV)重复单元的聚酰胺酸：1（其中，R1和R2代表H或C1至C20烷基，Z代表缩聚的多环芳族基或以下式的基团：2，其中，X代表—CO—或—C(═N2)—，Y代表直接键，—CH2—，—O—，—SO2—，—S—，—CO—或—C(═N2)—，W代表直接键，—CH2—，—C(CH3)2—，—C(CF3)2—，—S—，—SO—，—SO2或—O—。b，m和n为0或1；r为C1至4烷基，卤素基或苯基；a为0或1至3。）