1-chloro-7-methoxy-9H-xanthen-9-one | 86456-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-chloro-7-methoxy-9H-xanthen-9-one
• 英文别名: 1-chloro-7-methoxyxanthone；1-Chloro-7-methoxyxanthen-9-one
• CAS: 86456-14-6
• 化学式: C₁₄H₉ClO₃
• 分子量: 260.677
• InChiKey: KTYOHESTZQMKCZ-UHFFFAOYSA-N

物化性质

• 沸点：
  418.7±45.0 °C(Predicted)
• 密度：
  1.375±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-chloro-7-methoxy-9H-xanthen-9-one 生成 1-<<2-(diethylamino)ethyl>amino>-7-methoxy-9H-xanthen-9-one
  参考文献：
  名称：

  ARCHER, S.

  摘要：

  DOI：
• 作为产物：
  描述：

  1-氯-3-碘苯 在 copper(l) iodide 、 PPA 、 铜 、 potassium carbonate 作用下， 反应 53.17h， 生成 1-chloro-7-methoxy-9H-xanthen-9-one
  参考文献：
  名称：

  Analogs of hycanthone and lucanthone as antitumor agents

  摘要：

  Hycanthone analogues (5 and 6) containing 7-substituted hydroxyl groups were prepared and evaluated as antitumor agents. These compounds were significantly more active than the corresponding unsubstituted derivatives. The 7-hydroxylated 4-(hydroxymethyl)-9H-xanthen-9-ones, 11 and 12, were also active antitumor agents. However, the 7-hydroxy-9H-xanthen-9-one counterparts of the 7-hydroxylucanthones were totally devoid of antitumor activity. Results obtained thus far are consistent with the hypothesis that 4-hydroxymethyl substituents in the 9H-xanthen-9-one and 9H-thioxanthen-9-one series are required for antitumor activity.

  DOI：

  10.1021/jm00363a007

文献信息

• Non-linear optical device
  申请人：HITACHI, LTD.

  公开号：EP0315140A2

  公开（公告）日：1989-05-10

  According to the present invention, there is provided a non-linear optical device comprising a non-linear optical medium comprising an organic compound, which remarkably improves the non-linear optical properties. The non-linear optical device according to the present invention is suited for the second and third harmonic generations, photomixing optical parametric oscillations, optical switches and optical bistable devices.

  根据本发明，提供了一种非线性光学器件，它包括一种由有机化合物组成的非线性光学介质，可显著改善非线性光学特性。本发明的非线性光学器件适用于二次和三次谐波代、光混合光学参量振荡、光学开关和光学双稳态器件。
• US5176854A
  申请人：——

  公开号：US5176854A

  公开（公告）日：1993-01-05