Sontigidomide | 2560577-69-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: Sontigidomide
• 英文别名: N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2-oxo-2-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]acetamide
• CAS: 2560577-69-5
• 化学式: C₂₆H₂₂F₃N₃O₅
• 分子量: 513.5
• InChiKey: SKAIDPMCBUKTDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• PROTEIN-TARGETING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS
  申请人：BioTheryX, Inc.

  公开号：US20200369679A1

  公开（公告）日：2020-11-26

  The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

  本公开提供了化合物，例如式（I）的化合物，其调节蛋白功能和/或恢复蛋白稳态。该公开提供了一种调节蛋白介导的疾病、紊乱、状况或反应的方法。还提供了与其他治疗剂结合的组合物。
• Protein-targeting compounds and pharmaceutical compositions thereof, and their therapeutic applications
  申请人：BioTheryX, Inc.

  公开号：US11345712B2

  公开（公告）日：2022-05-31

  The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.

  本公开提供了调节蛋白质功能和/或恢复蛋白质平衡的化合物，例如式（I）化合物。本公开提供了一种调节蛋白质介导的疾病、失调、状况或反应的方法。提供了包括与其他治疗剂组合的组合物。
• [EN] COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] COMPOSÉS CIBLANT DES PROTÉINES ET LEURS COMPOSITIONS PHARMACEUTIQUES, ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：BIOTHERYX INC

  公开号：WO2020242960A1

  公开（公告）日：2020-12-03

  The present disclosure provides compounds, for example, a compound of Formula (I), that modulate a protein function and/ or restore protein homeostasis. The disclosure provides a method of modulating a protein-mediated disease, disorder, condition, or response. Compositions, including in combination with other therapeutic agents, are provided.