CP 2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: CP 2
• 英文别名: (A.7) 3-(2-chloropyrid-5-ylmethyl)-4-nitroimino-perhydro-1,3,5-oxadiazine；(A.7) 5-(2-chloropyrid-5-ylmethyl)-4-nitroimino-perhydro-1,3,5-oxadiazine；(NZ)-N-[3-[(6-chloropyridin-3-yl)methyl]-1,3,5-oxadiazinan-4-ylidene]nitramide
• 化学式: C₉H₁₀ClN₅O₃
• 分子量: 271.663
• InChiKey: RHEABVUOLZOFCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PESTICIDAL COMPOSITIONS
  申请人：Syngenta Participations AG

  公开号：EP0900024B1

  公开（公告）日：2003-06-18
• The discovery of thiamethoxam: a second-generation neonicotinoid
  作者：Peter Maienfisch、Hanspeter Huerlimann、Alfred Rindlisbacher、Laurenz Gsell、Hansruedi Dettwiler、Joerg Haettenschwiler、Evelyne Sieger、Markus Walti

  DOI：10.1002/1526-4998(200102)57:2<165::aid-ps289>3.0.co;2-g

  日期：2001.2

  Neonicotinoids represent a novel and distinct chemical class of insecticides with remarkable chemical and biological properties. In 1985, a research programme was started in this field, in which novel nitroimino heterocycles were designed, prepared and assayed for insecticidal activity. The methodology for the synthesis of 2-nitroimino-hexahydro-1,3,5-triazines, 4-nitroimino-1,3,5-oxadiazinanes and 4-nitroimino-1,3,5-thiadiazinanes is outlined. Bioassays demonstrated that 3-(6-chloropyridin-3-ylmethyl)-4-nitroimino-1,3,5-oxadiazinane exhibited better insecticidal activity than the corresponding 2-nitroimino-hexahydro-1,3,5-triazine and 4-nitroimino-1,3,5-thiadiazinane. In most tests, this compound was equally or only slightly less active than imidacloprid. A series of structural modifications on this lead structure revealed that replacement of the 6-chloro-3-pyridyl group by a 2-chloro-5-thiazolyl moiety resulted in a strong increase of activity against chewing insects, whereas the introduction of a methyl group as pharmacophore substituent increased activity against sucking pests. The combination of these two favourable modifications led to thiamethoxam (CGA 293 343).Thiamethoxam is the first commercially available second-generation neonicotinoid and belongs to the thianicotinyi sub-class. It is marketed under the trademarks Actara(R) for foliar and soil treatment and Cruiser(R) for seed treatment. The compound has broad-spectrum insecticidal activity and offers excellent control of a wide variety of commercially important pests in many crops. Low use rates, flexible application methods, excellent efficacy and the favourable safety profile make this new insecticide well-suited for modern integrated pest management programmes in many cropping systems. (C) 2001 Society of Chemical Industry.
• PESTICIDAL COMPOSITION
  申请人：Syngenta Participations AG

  公开号：EP0915656B1

  公开（公告）日：2003-07-23
• ZYKLISCHE GUANIDIN-DERIVATE UND IHRE VERWENDUNG ALS PESTIZIDE
  申请人：Bayer CropScience AG

  公开号：EP1144407B1

  公开（公告）日：2003-06-04
• FLY GEL BAIT
  申请人：Bayer CropScience AG

  公开号：EP1853111B1

  公开（公告）日：2010-01-13