5-(Trimethylstannyl)-2,3-dihydrofuran | 119529-00-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 5-(Trimethylstannyl)-2,3-dihydrofuran
• 英文别名: (4,5-Dihydrofuran-2-yl)trimethylstannane；2,3-dihydrofuran-5-yl(trimethyl)stannane
• CAS: 119529-00-9
• 化学式: C₇H₁₄OSn
• 分子量: 232.898
• InChiKey: RQPKUOIIPHQXDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.17
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-氨基-6-溴苯腈 、 5-(Trimethylstannyl)-2,3-dihydrofuran 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 反应 1.5h， 以68%的产率得到2-amino-6-(4,5-dihydrofuran-2-yl)benzonitrile
  参考文献：
  名称：

  METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER

  摘要：

  本发明涉及一种在暴露于光源时稳定一种或多种甜味增强剂的方法，以及含有一种或多种甜味增强剂和一种或多种光稳定剂的液体组合物。

  公开号：

  US20150245642A1

文献信息

• Studies in cuprate rearrangement and stannylcupration: Application to the stereo- and enantiospecific synthesis of a stannyldiene C10–C15 fragment of des-epoxy-rosaramycin
  作者：Valérie Fargeas、Patrick Le Ménez、Isabelle Berque、Janick Ardisson、Ange Pancrazi

  DOI：10.1016/0040-4020(96)00315-8

  日期：1996.5

  Metallate rearrangements were performed on α-(carbamoyloxy)alkenyl stannanes 4 in high yields to prepare (±)-8a and (±)-8b via alkyl transfer but failed when stannyl and stannylvinyl transfers were attempted to give 10ab and 1ab after quenching with Mel. After we optimized conditions on dihydrofuran 13, a model study, the dihydrofuran 19 could deliver cuprate rearrangements, leading after methylation

  以高收率对α-（氨基甲酰氧基）烯基锡烷4进行金属化物重排，以通过烷基转移制备（±）-8a和（±）-8b，但当尝试用苯乙烯淬灭后用苯乙烯基和苯乙烯基乙烯基转移得到10ab和1ab时失败。。在我们优化了模型研究的二氢呋喃13的条件后，二氢呋喃19可以传递铜酸盐重排，甲基化后导致苯乙烯基衍生物10和苯乙烯基二烯1丰产。设想了通过使用（E）-1,2-双（三丁基锡烷基）乙烯11的Stille Pd（0）偶联反应来合成苯乙烯基二烯的第二种方法。一种有效的方法是通过对烯炔（±）-24进行锡烷基化，从而以高收率和较高的区域和立体控制得到预期的锡烷基二烯（±）-1。
• MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH
  申请人：Tachdjian Catherine

  公开号：US20110224155A1

  公开（公告）日：2011-09-15

  The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

  本发明包括识别化学感受受体及其配体的修饰剂的方法，例如通过确定测试实体是否适合与化学感受受体的捕蝇草结构域中的一个或多个相互作用位点发生相互作用，并且能够调节化学感受受体及其配体的修饰剂。本发明还包括化学感受受体及其配体的修饰剂，其具有式（I）、其亚属和具体化合物。此外，本发明还包括包含化学感受受体及其配体的修饰剂的可食用组合物以及使用化学感受受体及其配体的修饰剂增强可食用组合物的甜味或治疗与化学感受受体相关的疾病的方法。此外，本发明还包括制备化学感受受体及其配体的修饰剂的过程。
• Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
  申请人：Tachdjian Catherine

  公开号：US09000054B2

  公开（公告）日：2015-04-07

  The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

  本发明涉及一种在暴露于光源时稳定一种或多种甜味增强剂的方法，以及含有一种或多种甜味增强剂和一种或多种光稳定剂的液体组合物。
• Modulation of chemosensory receptors and ligands associated therewith
  申请人：Tachdjian Catherine

  公开号：US08633186B2

  公开（公告）日：2014-01-21

  The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.

  本发明涉及识别化学感受器及其配体的修饰剂的方法，例如，通过确定测试实体是否适合与化学感受器的食虫植物结构域内的一个或多个相互作用位点相互作用来确定。本发明还包括能够调节化学感受器及其配体的修饰剂。本发明还包括具有公式（I）、其亚属和特定化合物的化学感受器及其配体的修饰剂。此外，本发明包括包含化学感受器及其配体的修饰剂的可食用组合物，并使用化学感受器及其配体的修饰剂来增强可食用组合物的甜味或治疗与化学感受器相关的疾病的方法。此外，本发明还包括制备化学感受器及其配体的修饰剂的方法。
• A stereoselective synthesis of functionalized alkenyllithiums and alkenyl cyanocuprates by the copper(I)-catalyzed coupling of organolithium reagents with .alpha.-lithiated cyclic enol ethers
  作者：Philip Kocienski、Sjoerd Wadman、Kelvin Cooper

  DOI：10.1021/ja00188a095

  日期：1989.3