Fmoc-iminodipropionic acid | 377087-65-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-iminodipropionic acid
• 英文别名: 3-[2-carboxyethyl(9H-fluoren-9-ylmethoxycarbonyl)amino]propanoic acid
• CAS: 377087-65-5
• 化学式: C₂₁H₂₁NO₆
• 分子量: 383.401
• InChiKey: DUZRLPKOGSOKML-UHFFFAOYSA-N

物化性质

• 沸点：
  636.5±48.0 °C(Predicted)
• 密度：
  1.345±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Fmoc-iminodipropionic acid 、 H-Adoa-Thr(t-Bu)-Lys(Boc)-Pro-Pro-Arg(Pmc)-Ot-Bu 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  A new dendrimer scaffold for preparing dimers or tetramers of biologically active molecules

  摘要：

  Synthesis of a new scaffold derived from iminodipropionic acid for the preparation of peptide dimers and tetramers is described. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.026
• 作为产物：
  描述：

  3-[(2-tert-Butoxycarbonyl-ethyl)-(9H-fluoren-9-ylmethoxycarbonyl)-amino]-propionic acid tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以75%的产率得到Fmoc-iminodipropionic acid
  参考文献：
  名称：

  A new dendrimer scaffold for preparing dimers or tetramers of biologically active molecules

  摘要：

  Synthesis of a new scaffold derived from iminodipropionic acid for the preparation of peptide dimers and tetramers is described. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.026

文献信息

• Compounds for Targeting Endothelial Cells, Compositions Containing the Same and Methods for Their Use
  申请人：Von Wronski Mathew A.

  公开号：US20120315220A1

  公开（公告）日：2012-12-13

  The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.

  本发明提供了用于靶向内皮细胞、肿瘤细胞或其他表达NP-1受体的细胞的化合物，以及含有这些化合物的组合物和使用它们的方法。此外，本发明还包括用于可视化、治疗或放射治疗的诊断、治疗和放射治疗组合物。
• COMPOUNDS FOR TARGETING ENDOTHELIAL CELLS, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR THEIR USE
  申请人：Von Wronski Mathew A.

  公开号：US20110262366A1

  公开（公告）日：2011-10-27

  The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.

  本发明提供了用于靶向内皮细胞、肿瘤细胞或其他表达NP-1受体的细胞的化合物，包含这些化合物的组合物以及它们的使用方法。此外，本发明还包括用于可视化、治疗或放射治疗的诊断、治疗和放射治疗组合物。
• Compounds for targeting endothelial cells
  申请人：Bracco Suisse SA

  公开号：EP2279757A2

  公开（公告）日：2011-02-02

  The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.

  本发明提供了靶向内皮细胞、肿瘤细胞或其他表达 NP-1 受体的细胞的化合物、含有这些化合物的组合物及其使用方法。此外，本发明还包括用于可视化、治疗或放射治疗的诊断、治疗和放射治疗组合物。
• COMPOUNDS USEFUL IN PREPARING HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE
  申请人：Capon, Daniel J.

  公开号：EP3701971A1

  公开（公告）日：2020-09-02

  The present invention provides intermediate compounds containing a triazine or trans-cyclooctene group, useful in the preparation of compounds having the structure:         A-B-----Z wherein A is a biologically active structure of the compound; wherein Z is a protein component of the compound, which protein component comprises one or more polypeptides, wherein at least one of the one or more polypeptides comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fc receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine or selenocysteine; wherein the dashed line between B and Z represents a peptidyl linkage; and wherein the solid line between A and B represents a nonpeptidyl linkage.

  本发明提供了含有三嗪或反式环辛烯基团的中间体化合物，可用于制备具有以下结构的化合物： A-B-----Z 其中，A 是化合物的生物活性结构；Z 是化合物的蛋白质成分，该蛋白质成分包括一个或多个多肽，其中一个或多个多肽中至少有一个多肽包括连续氨基酸，这些连续氨基酸(i) 与抗体 Fc 结构域链中存在的一段连续氨基酸相同；(ii)与 Fc 受体结合；以及(iii)在其 N 端具有选自半胱氨酸或硒半胱氨酸组成的组的序列；其中 B 和 Z 之间的虚线代表肽基连接；而 A 和 B 之间的实线代表非肽基连接。
• Hybrid immunoglobulin containing non-peptidyl linkage
  申请人：Biomolecular Holdings LLC

  公开号：US11066459B2

  公开（公告）日：2021-07-20

  The present invention provides a compound having the structure: A-B - - - Z wherein A is a biologically active structure of the compound; wherein Z is a protein component of the compound, which protein component comprises one or more polypeptides, wherein at least one of the one or more polypeptides comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fc receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine or selenocysteine; wherein the dashed line between B and Z represents a peptidyl linkage; and wherein the solid line between A and B represents a nonpeptidyl linkage, as well as intermediates dimers thereof, and processes of producing the compounds of the invention.

  本发明提供了一种具有以下结构的化合物： A-B - - Z 其中 A 是该化合物的生物活性结构；其中 Z 是该化合物的蛋白质组分，该蛋白质组分包括一个或多个多肽，其中一个或多个多肽中的至少一个多肽包括连续氨基酸，这些连续氨基酸(i) 与抗体的 Fc 结构域链中存在的一段连续氨基酸相同；(ii)与 Fc 受体结合；(iii)在其 N 端具有选自由半胱氨酸或硒半胱氨酸组成的组的序列；其中 B 和 Z 之间的虚线表示肽基连接；A 和 B 之间的实线表示非肽基连接，以及其中间体二聚体，以及生产本发明化合物的工艺。