| 1246087-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• CAS: 1246087-03-5
• 化学式: C₃₀H₃₂ClN₃O₆S₂
• 分子量: 630.186
• InChiKey: CIFOJXBSUKIXFC-LHAKGSKCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.09
• 重原子数：
  42.0
• 可旋转键数：
  7.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  138.75
• 氢给体数：
  5.0
• 氢受体数：
  11.0

反应信息

• 作为产物：
  描述：

  葡萄糖 、 2-(4-Chlorophenyl)-6-phenylspiro[4,10-dithia-1,6,8-triazatricyclo[7.3.0.03,7]dodeca-3(7),8-diene-5,1'-cyclohexane]-12-one 在 溶剂黄146 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 4.0h， 以55%的产率得到
  参考文献：
  名称：

  Facile Novel Synthesis and Reactions of Thiazolidin-4-one Derivatives for Antimicrobial Agents

  摘要：

  A facile and fast procedure for synthesis of 3-phenyl-cyclohexane(1'-2)thiazolidin-4-one (1), which underwent condensation with glucose and p-chlorobenzaldehyde to afford 2 and 3, respectively. Compound 3 was used as precursor for the preparation of some fused heterocyclic compounds 4-7. Compound 4 was alkylated using dichloroacetone and chloroacetic acid to afford 8 and 9, respectively. Also, it reacted with acrylonitrile and hydrazine hydrate to afford 10 and 11, respectively. Compound 9 was condensed with p-chlorobenzaldehyde and glucose to afford 12 and 13, respectively. Selected members of the synthesized compounds were screened for antimicrobial activity.

  DOI：

  10.1080/00397910903318674