N-(adamantan-1-ylmethyl)-2-[(2-methyl-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)carbonyl]pyrazolo[1,5-a]pyridine-4-carboxamide | 1069068-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: N-(adamantan-1-ylmethyl)-2-[(2-methyl-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidin-6(4H)-yl)carbonyl]pyrazolo[1,5-a]pyridine-4-carboxamide
• 英文别名: N-(1-adamantylmethyl)-2-(2-methyl-4-oxo-3,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carbonyl)pyrazolo[1,5-a]pyridine-4-carboxamide
• CAS: 1069068-75-2
• 化学式: C₂₈H₃₂N₆O₃
• 分子量: 500.6
• InChiKey: YZUUTOOJTMORTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  37
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS
  申请人：Ihle David C.

  公开号：US20100266509A1

  公开（公告）日：2010-10-21

  Heteroaryl amide analogues are provided, of Formula (I), wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了异芳基酰胺类似物，其化学式为（I），其中变量如本文所述。这些化合物是配体，可用于体内或体外调节特定受体活性，并在治疗人类、家养伴侣动物和家畜动物的与病理受体激活相关的疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究的配体使用方法。
• Heteroaryl amide analogues as p2x7 antagonists
  申请人：H. Lundbeck A/S

  公开号：EP2592082A1

  公开（公告）日：2013-05-15

  Heteroaryl amide analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  提供了杂芳基酰胺类似物，其分子式为 其中变量如本文所述。此类化合物是可用于调节体内或体外特异性受体活性的配体，特别适用于治疗与人类、驯养的伴侣动物和家畜的病理受体激活有关的疾病。本文提供了使用此类化合物治疗此类疾病的药物组合物和方法，以及使用此类配体进行受体定位研究的方法。
• US8580812B2
  申请人：——

  公开号：US8580812B2

  公开（公告）日：2013-11-12
• [EN] HETEROARYL AMIDE ANALOGUES AS P2X7 ANTAGONISTS<br/>[FR] ANALOGUES D'HETEROARYL-AMIDES UTILISES EN TANT QU'ANTAGONISTES DE P2X7
  申请人：NEUROGEN CORP

  公开号：WO2008124153A1

  公开（公告）日：2008-10-16

  [EN] Heteroaryl amide analogues are provided, of Formula (I), wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.
  [FR] L'invention concerne des analogues d'hétéroaryl-amides de Formula (I), dans laquelle les variables sont telles que définies dans la description. Ces composés sont des ligands qui peuvent être utilisés pour moduler une activité de récepteur spécifique in vivo ou in vitro et qui sont particulièrement utiles dans le traitement d'affections associées à une activation de récepteur pathologique chez des humains, des animaux domestiques et des animaux d'élevage. L'invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation de ces composés dans le traitement de ces troubles, ainsi que des méthodes d'utilisation de ces ligands dans des études de localisation de récepteurs.