4-[3-(2-氯-10H-吩噻嗪-10-基)丙基]哌嗪-1-乙醇盐酸盐

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 4-[3-(2-氯-10H-吩噻嗪-10-基)丙基]哌嗪-1-乙醇盐酸盐
• 英文名称: 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol;hydron;chloride
• 化学式: C21H27Cl2N3OS
• 分子量: 440.4
• InChiKey: ONDBZOZCVLIFKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.36
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Lipid-rich plaque inhibitors
  申请人：——

  公开号：US20030232809A1

  公开（公告）日：2003-12-18

  The present invention provides a lipid-rich plaque regressing agent comprising a compound represented by Formula: 1 in which ring A is a cyclic hydrocarbon or the like; ring B is a heterocyclic ring or the like; each of X and Y is —NR 1 — (in which R 1 is a hydrocarbon or the like); D is a C 1-3 alkylene group or the like; E is —NH— or the like; G is a bond or the like; and Ar is an aryl or the like; D may be taken together with a constituent atom of the ring B to form a ring, and R 4 may be taken together with a constituent atom of the ring B to form a ring.

  本发明提供了一种富含脂质的斑块退行剂，包括一种由式:1所代表的化合物，其中环A是环烃或类似物；环B是杂环或类似物；X和Y中的每一个是—NR1—（其中R1是烃或类似物）；D是C1-3烷基或类似物；E是—NH—或类似物；G是键或类似物；Ar是芳基或类似物；D可以与环B的一个构成原子结合形成环，R4可以与环B的一个构成原子结合形成环。
• COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES
  申请人：Johansen Lisa M.

  公开号：US20100009970A1

  公开（公告）日：2010-01-14

  The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

  本发明涉及用于治疗病毒性疾病的组合物、方法和试剂盒。在某些实施方式中，病毒性疾病是由单链RNA病毒、黄病毒科病毒或肝病毒引起的。在特定实施方式中，病毒性疾病是病毒性肝炎（例如甲型肝炎、乙型肝炎、丙型肝炎、丁型肝炎、戊型肝炎），药剂或药剂组合包括舍曲林、舍曲林类似物、UK-416244或UK-416244类似物。还包括用于鉴定可用于治疗病毒性疾病的新化合物的筛选方法。
• Lipid-rich plaque regressing agents
  申请人：Terashita Zen-ichi

  公开号：US20060035865A1

  公开（公告）日：2006-02-16

  The present invention provides a lipid-rich plaque regressing agent comprising a compound represented by Formula: in which ring A is a cyclic hydrocarbon or the like; ring B is a heterocyclic ring or the like; each of X and Y is —NR 1 — (in which R 1 is a hydrocarbon or the like); D is a C 1-3 alkylene group or the like; E is —NH— or the like; G is a bond or the like; and Ar is an aryl or the like; D may be taken together with a constituent atom of the ring B to form a ring, and R 4 may be taken together with a constituent atom of the ring B to form a ring.

  本发明提供了一种脂质富集斑块消退剂，其包括以下式子所代表的化合物：其中，环A是环烃或类似物；环B是杂环或类似物；X和Y中的每一个均为—NR1—（其中R1为碳氢化合物或类似物）；D是C1-3烷基或类似物；E是—NH—或类似物；G是键或类似物；Ar是芳基或类似物；D可以与环B的组成原子结合形成环，而R4可以与环B的组成原子结合形成环。
• Controlled release pharmaceutical composition
  申请人：Euroceltique S.A.

  公开号：EP0214735A1

  公开（公告）日：1987-03-18

  A solid, controlled release, pharmaceutical composition comprising a drug and an anionic surfactant, incorporated in a matrix comprising a hydrophilic polymer, wherein the drug is either an acid addition salt of an organic base or a quaternary ammonium salt, provided that,. the organic base is not propranolol or chlorpheniramine. Preferably the drug is an acid addition salt of an organic amine, the surfactant is a sulphosuccinate and the polymer is a water-soluble hydroxyalkyl cellulose ether.

  一种固体控释药物组合物，由药物和阴离子表面活性剂组成，掺入由亲水性聚合物组成的基质中，其中药物为有机碱的酸加成盐或季铵盐，条件是：有机碱不是普萘洛尔或氯苯那敏。 药物最好是有机胺的酸加成盐，表面活性剂是磺基琥珀酸酯，聚合物是水溶性羟烷基纤维素醚。
• LIPID-RICH PLAQUE INHIBITORS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1302470A1

  公开（公告）日：2003-04-16

  The present invention provides a lipid-rich plaque regressing agent comprising a compound represented by Formula: in which ring A is a cyclic hydrocarbon or the like; ring B is a heterocyclic ring or the like; each of X and Y is -NR1- (in which R1 is a hydrocarbon or the like); D is a C1-3 alkylene group or the like; E is -NH- or the like; G is a bond or the like; and Ar is an aryl or the like; D may be taken together with a constituent atom of the ring B to form a ring, and R4 may be taken together with a constituent atom of the ring B to form a ring.

  本发明提供了一种富含脂质的斑块消退剂，它包含由式表示的化合物： 其中环 A 是环状烃或类似物；环 B 是杂环或类似物；X 和 Y 各为-NR1-（其中 R1 是烃或类似物）；D 是 C1-3 烯基或类似物；E 是-NH- 或类似物；G 是键或类似物；Ar 是芳基或类似物；D 可与环 B 的一个组成原子共同形成一个环，R4 可与环 B 的一个组成原子共同形成一个环。