Chlormethyl-<2-naphthyl>sulfon | 10341-51-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Chlormethyl-<2-naphthyl>sulfon
• 英文别名: Chlormethyl-(2-naphthyl)sulfon；2-(Chloromethylsulfonyl)naphthalene
• CAS: 10341-51-2
• 化学式: C₁₁H₉ClO₂S
• 分子量: 240.71
• InChiKey: QWDHTVYBBQEBKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Chlormethyl-<2-naphthyl>sulfon 、 对氟硝基苯 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT₆ Receptor Antagonists

  摘要：

  Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure activity relationship of this potent class are discussed.

  DOI：

  10.1021/jm901674f
• 作为产物：
  描述：

  溴氯甲烷 、 2-萘磺酰氯 在 四丁基溴化铵 、 碳酸氢钠 、 sodium sulfite 作用下， 以 水 为溶剂， 生成 Chlormethyl-<2-naphthyl>sulfon
  参考文献：
  名称：

  5-Cyclic Amine-3-arylsulfonylindazoles as Novel 5-HT₆ Receptor Antagonists

  摘要：

  Novel 5-cyclic amine-3-arylsulfonylindazoles were prepared, and several analogues within this class have been identified as high-affinity 5-HT6 receptor ligands with improved pharmacokinetic and pharmacological properties. One selected example, 18b, showed good brain penetrability and a generally favorable pharmacokinetic profile with procognitive efficacy in the rat novel object recognition assay. The synthesis and structure activity relationship of this potent class are discussed.

  DOI：

  10.1021/jm901674f