(Z)-4-(6-bromo-2-methoxyquinolin-3-yl)-N,N-dimethyl-4-phenyl-3-thiophen-3-ylbut-3-en-1-amine | 1032468-64-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (Z)-4-(6-bromo-2-methoxyquinolin-3-yl)-N,N-dimethyl-4-phenyl-3-thiophen-3-ylbut-3-en-1-amine
• CAS: 1032468-64-6
• 化学式: C₂₆H₂₅BrN₂OS
• 分子量: 493.467
• InChiKey: IXWRRBMDLQFQRF-LVWGJNHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  53.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(6-Bromo-2-methoxy-3-quinolyl)-4-(dimethylamino)-1-phenyl-2-(3-thienyl)butan-2-ol 在 吡啶 、 氯化亚砜 作用下， 以8%的产率得到(E)-4-(6-bromo-2-methoxyquinolin-3-yl)-N,N-dimethyl-4-phenyl-3-thiophen-3-ylbut-2-en-1-amine
  参考文献：
  名称：

  WO2008/68266

  摘要：

  公开号：

文献信息

• ANTIBACTERIAL QUINOLINE DERIVATIVES
  申请人：Guillemont Jérôme Emile Georges

  公开号：US20100069366A1

  公开（公告）日：2010-03-18

  The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, wherein Q represents a radical of formula a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.