2-carbamoylmethylthio-4-chloro-N-(3,4-dihydro-4-oxoquinazolin-2-yl)-5-methylbenzenesulfonamide | 1421611-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-carbamoylmethylthio-4-chloro-N-(3,4-dihydro-4-oxoquinazolin-2-yl)-5-methylbenzenesulfonamide
• CAS: 1421611-04-2
• 化学式: C₁₇H₁₅ClN₄O₄S₂
• 分子量: 438.915
• InChiKey: UFHSFJLDRMNYLQ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  、 邻氨基苯甲酸甲酯 以 溶剂黄146 为溶剂， 以41%的产率得到2-carbamoylmethylthio-4-chloro-N-(3,4-dihydro-4-oxoquinazolin-2-yl)-5-methylbenzenesulfonamide
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel 4-chloro-2-mercaptobenzenesulfonamide derivatives

  摘要：

  Few series of novel 4-chloro-2-mercaptobenzenesulfonamides have been synthesized by the reactions of N-(benzenesulfonyl) cyanamide potassium salts 7-15 with corresponding hydrazinecarbodithioic acid esters, 1-substituted carbothioic acid hydrazides, methyl 3-aminothiophene-2-carboxylate, methyl 2-aminobenzoate, 2-aminophenol or 2-aminothiophenol. The synthesized compounds (16-49) were screened in vitro for their antibacterial activity. Some of the tested compounds 16, 17, 23, 24, 31, 32 and 48 showed the promising activity against many of anaerobic Gram-positive bacteria strains.

  DOI：

  10.3109/14756366.2011.625024