N,N-dimethyl(3-ethyl-2-oxaadamant-1-yl)amine | 1160355-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: N,N-dimethyl(3-ethyl-2-oxaadamant-1-yl)amine
• 英文别名: 3-ethyl-N,N-dimethyl-2-oxatricyclo[3.3.1.13,7]decan-1-amine
• CAS: 1160355-58-7
• 化学式: C₁₃H₂₃NO
• 分子量: 209.332
• InChiKey: WHLCHZNWMBDKMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl(3-ethyl-2-oxaadamant-1-yl)amine 在 hydrochloric acid diethyl ether 作用下， 以 乙醚 为溶剂， 以110 mg的产率得到N,N-dimethyl(3-ethyl-2-oxaadamant-1-yl)amine hydrochloride
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

  摘要：

  The synthesis of several (2-oxaadamant-1-yl) amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.02.007
• 作为产物：
  描述：

  聚合甲醛 、 (3-ethyl-2-oxaadamant-1-yl)amine 在 甲酸 、 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 反应 0.25h， 生成 N,N-dimethyl(3-ethyl-2-oxaadamant-1-yl)amine
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

  摘要：

  The synthesis of several (2-oxaadamant-1-yl) amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.02.007

文献信息

• Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
  作者：María D. Duque、Pelayo Camps、Lenuta Profire、Silvia Montaner、Santiago Vázquez、Francesc X. Sureda、Jordi Mallol、Marta López-Querol、Lieve Naesens、Erik De Clercq、S. Radhika Prathalingam、John M. Kelly

  DOI：10.1016/j.bmc.2009.02.007

  日期：2009.4

  The synthesis of several (2-oxaadamant-1-yl) amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity. (C) 2009 Elsevier Ltd. All rights reserved.