[(tricyclo[3.3.1.0(3,7)]non-3-yl)methyl]amine | 1100395-68-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [(tricyclo[3.3.1.0(3,7)]non-3-yl)methyl]amine
• 英文别名: C-(Hexahydro-2,5-methano-pentalen-3a-yl)-methylamine；3-tricyclo[3.3.1.03,7]nonanylmethanamine
• CAS: 1100395-68-3
• 化学式: C₁₀H₁₇N
• mdl: MFCD20547696
• 分子量: 151.252
• InChiKey: WSOOPHBNNKGWGN-UHFFFAOYSA-N

物化性质

• 沸点：
  208.0±8.0 °C(Predicted)
• 密度：
  1.071±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [(tricyclo[3.3.1.0(3,7)]non-3-yl)methyl]amine 在 hydrochloric acid diethyl ether 作用下， 以 二氯甲烷 、 水 为溶剂， 以613 mg的产率得到[(tricyclo[3.3.1.0(3,7)]non-3-yl)methyl]amine hydrochloride
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

  摘要：

  The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.028
• 作为产物：
  描述：

  hexahydro-2,5-methanopentalene-3a(1H)-carboxamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 生成 [(tricyclo[3.3.1.0(3,7)]non-3-yl)methyl]amine
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

  摘要：

  The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.10.028

文献信息

• [EN] DERIVATIVES OF MULTI-RING AROMATIC COMPOUNDS AND USES AS ANTI-TUMOR AGENTS<br/>[FR] DÉRIVÉS DE COMPOSÉS AROMATIQUES À NOYAUX MULTIPLES ET UTILISATIONS COMME AGENTS ANTI-TUMORAUX
  申请人：AVALON PHARMACEUTICALS

  公开号：WO2010082912A1

  公开（公告）日：2010-07-22

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本文披露了化学试剂，如萘、蒽、联苯并呋喃、二苯并吡喃和吖啶的二磺酰胺衍生物等，以及类似的杂环环结构，包括其盐，作为抗癌和抗肿瘤试剂，并披露了制备这些试剂的方法，以及含有这些试剂作为活性成分的药物组合物，以及使用这些试剂作为治疗试剂的方法。
• Annulated carbamates are precursors for the ring contraction of the adamantane framework
  作者：Radim Hrdina、Oksana M. Holovko-Kamoshenkova、Ivana Císařová、Filip Koucký、Oldřich Machalický

  DOI：10.1039/d2ra06402b

  日期：——

  We report a protocol for the one-pot two-step synthesis of noradamantane methylene amines.

  我们报告了一种一步法两步合成正金刚烷亚甲基胺的方案。
• [EN] DERIVATIVES OF FLUORENE, ANTHRACENE, XANTHENE, DIBENZOSUBERONE AND ACRIDINE AND USES THEREOF<br/>[FR] DÉRIVÉS DU FLUORÈNE, DE L'ANTHRACÈNE, DU XANTHÈNE, DU DIBENZOSUBÉRONE ET DE L'ACRIDINE ET LEURS UTILISATIONS
  申请人：AVALON PHARMACEUTICALS

  公开号：WO2008140792A1

  公开（公告）日：2008-11-20

  [EN] Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/ß-catenin signaling pathway, and serve to reduce ß-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.
  [FR] La présente invention concerne des agents chimiques, tels que les dérivés disulfonamide du fluorène, de l'anthracène, du xanthène, du dibenzosubérone et de l'acridine, et des structures en anneaux hétérocycliques similaires, y compris leurs sels, qui agissent comme agents anticancéreux et antitumoraux, en particulier lorsque ces agents régulent l'activité de la voie de signalisation de la Wnt/ß-caténine et servent à réduire les niveaux de ß-caténine présents dans les cellules, telles que les cellules cancéreuses, ou lorsque les agents régulent les niveaux d'expression des gènes dans les systèmes cellulaires, y compris les cellules cancéreuses. La présente invention concerne également les procédés de préparation de ces agents, ainsi que des compositions pharmaceutiques les contenant en tant qu'ingrédients actifs et les procédés de leur utilisation comme agents thérapeutiques.