(1R,2S,3R,5S)-3-{6-[1-(5-chloro-pyridin-2-yl)-pyrrolidin-3(S)-ylamino]-purin-9-yl}-5-fluoromethyl-cyclopentane-1,2-diol | 636600-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (1R,2S,3R,5S)-3-{6-[1-(5-chloro-pyridin-2-yl)-pyrrolidin-3(S)-ylamino]-purin-9-yl}-5-fluoromethyl-cyclopentane-1,2-diol
• 英文别名: (1R,2S,3R,5S)-3-[6-[[(3S)-1-(5-chloropyridin-2-yl)pyrrolidin-3-yl]amino]purin-9-yl]-5-(fluoromethyl)cyclopentane-1,2-diol
• CAS: 636600-35-6
• 化学式: C₂₀H₂₃ClFN₇O₂
• 分子量: 447.9
• InChiKey: BXJCHJHBRVCIAV-KHEYOILXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Novel adenosine analogues and their use as pharmaceutical agents
  申请人：——

  公开号：US20040127434A1

  公开（公告）日：2004-07-01

  The present invention relates to compounds according to the general formula (I) 1 wherein R 1 , A, B, Q, T, W and X have the meanings given in the description. These compounds are useful for the manufacture of a medicament for the treatment of insulin resistance, type 2 diabetes, metabolic syndrome, lipid disorders or cardiovasular disease or for providing an anti-lipolytic effect.

  本发明涉及符合通用公式（I）1的化合物，其中R1、A、B、Q、T、W和X的含义如描述中所述。这些化合物可用于制造用于治疗胰岛素抵抗、2型糖尿病、代谢综合征、脂质紊乱或心血管疾病的药物，或者用于提供抗脂解效应。
• N6-substituted adenosine analogues and their use as pharmaceutical agents
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1375508A1

  公开（公告）日：2004-01-02

  The present invention relates to compounds according to the general formula (I) wherein R1, A, B, Q, T, W and X have the meanings given in the description. These compounds are useful for the manufacture of a medicament for the treatment of insulin resistance, type 2 diabetes, metabolic syndrome, lipid disorders or cardiovasular disease or for providing an anti-lipolytic effect.

  本发明涉及符合通式(I)的化合物，其中R1、A、B、Q、T、W和X具有描述中给出的含义。这些化合物可用于制造治疗胰岛素抵抗、2型糖尿病、代谢综合征、脂质紊乱或心血管疾病的药物，或提供抗脂解作用。
• US7265111B2
  申请人：——

  公开号：US7265111B2

  公开（公告）日：2007-09-04