| 1239876-34-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• CAS: 1239876-34-6
• 化学式: C₁₇H₂₄O₄
• 分子量: 292.375
• InChiKey: XAVYPWNNJBSDJC-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 水 、 sodium hydroxide 作用下， 生成 3-[2-hydroxy-4-methoxy-3-(3-methyl-but-2-enyl)-phenyl]-propionic acid
  参考文献：
  名称：

  Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus

  摘要：

  By use of the fission yeast expressing the model fusion protein comprised of GST, SV40 T antigen NLS, GFP, and Rev-NES in the bioassay, the prenylcoumarin osthol (1) was disclosed as the new Rev-export inhibitor from the MeOH extract of Cnidii Monnieris Fructus. Furthermore, 1 was also found to inhibit export the genuine Rev in HeLa cells by indirect fluorescent antibody technique. By the competitive experiment using the biotinylated probe 3, osthol (1) was revealed to inhibit nuclear export of Rev through a NES non-antagonistic mode. Structure-activity relationship analysis of several analogs of 1 clarified that both prenyl side chain and double bond adjacent to the lactone carbonyl residue play an important role in the Rev-export inhibitory potency of 1. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.081
• 作为产物：
  描述：

  以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus

  摘要：

  By use of the fission yeast expressing the model fusion protein comprised of GST, SV40 T antigen NLS, GFP, and Rev-NES in the bioassay, the prenylcoumarin osthol (1) was disclosed as the new Rev-export inhibitor from the MeOH extract of Cnidii Monnieris Fructus. Furthermore, 1 was also found to inhibit export the genuine Rev in HeLa cells by indirect fluorescent antibody technique. By the competitive experiment using the biotinylated probe 3, osthol (1) was revealed to inhibit nuclear export of Rev through a NES non-antagonistic mode. Structure-activity relationship analysis of several analogs of 1 clarified that both prenyl side chain and double bond adjacent to the lactone carbonyl residue play an important role in the Rev-export inhibitory potency of 1. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.081