1,1'-dicyclohexyl-3,3'-bidiaziridin | 5812-73-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1'-dicyclohexyl-3,3'-bidiaziridin
• 英文别名: 1-cyclohexyl-3-(1-cyclohexyldiaziridin-3-yl)diaziridine
• CAS: 5812-73-7
• 化学式: C₁₄H₂₆N₄
• mdl: MFCD00472964
• 分子量: 250.387
• InChiKey: DSHDNRNNEKAYLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N,N'-dicyclohexylethylenediimine 在 三乙胺 、 hydroxylamine-O-sulfonic acid 作用下， 以 甲醇 为溶剂， 反应 13.0h， 以76%的产率得到1,1'-dicyclohexyl-3,3'-bidiaziridin
  参考文献：
  名称：

  摘要：

  First representatives of 3,3'-bidiaziridines, viz., 1, 1 '-dialkyl - 3,3 '-bidiaziridines, were synthesized and isolated as mixtures of two diastereomers. In the case of Alk = Me, the diastereomers were separated. It was demonstrated by nuclear Overhauser effect experiments and X-ray diffraction analysis that the diastereomers are the racemate (rac-1R*,2R*,3S*, 1 'R*,2'R*,3' S*) and the meso-form (1S*,2S*,3R*, 1 'R*,2' R*,3' S*).

  DOI：

  10.1023/a:1011352905841

文献信息

• AGENTS FOR TREATING MENTAL DISORDERS
  申请人：CRO Consulting Limited

  公开号：EP2807150A2

  公开（公告）日：2014-12-03
• [EN] AGENTS FOR TREATING MENTAL DISORDERS<br/>[FR] AGENTS POUR LE TRAITEMENT DE TROUBLES MENTAUX
  申请人：CRO CONSULTING LTD

  公开号：WO2013111117A2

  公开（公告）日：2013-08-01

  The present invention relates to compounds of formula I, use of these compounds to treat mental and neurological disorders, especially depressions and psychoses of different etiology. The compounds provided for the treatment of mental and neurological disorders are presented by a general formula I: wherein R, R', R", Y are as defined in specification or pharmaceutically acceptable salts thereof, solvates thereof such as hydrates, and pharmaceutical compositions containing such compounds.
• ——
  作者：V. Yu. Petukhova、V. V. Kuznetzov、A. V. Shevtsov、Yu. A. Strelenko、N. N. Makhova、K. A. Lyssenko、M. Yu. Antipin

  DOI：10.1023/a:1011352905841

  日期：——

  First representatives of 3,3'-bidiaziridines, viz., 1, 1 '-dialkyl - 3,3 '-bidiaziridines, were synthesized and isolated as mixtures of two diastereomers. In the case of Alk = Me, the diastereomers were separated. It was demonstrated by nuclear Overhauser effect experiments and X-ray diffraction analysis that the diastereomers are the racemate (rac-1R*,2R*,3S*, 1 'R*,2'R*,3' S*) and the meso-form (1S*,2S*,3R*, 1 'R*,2' R*,3' S*).