5-[8-amino-2-[(3S)-piperidin-3-yl]imidazo[1,2-a]pyrazin-5-yl]thiophene-3-carboxylic acid | 960115-80-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 5-[8-amino-2-[(3S)-piperidin-3-yl]imidazo[1,2-a]pyrazin-5-yl]thiophene-3-carboxylic acid
• CAS: 960115-80-4
• 化学式: C₁₆H₁₇N₅O₂S
• 分子量: 343.409
• InChiKey: PZARDFAAQKAOJN-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS
  申请人：Zhao Lianyun

  公开号：US20080027063A1

  公开（公告）日：2008-01-31

  In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
• US7557104B2
  申请人：——

  公开号：US7557104B2

  公开（公告）日：2009-07-07
• [EN] IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS<br/>[FR] IMIDAZOPYRAZINES UTILISÉES EN TANT QU'INHIBITEUR DE PROTÉINE KINASE
  申请人：SCHERING CORP

  公开号：WO2007145921A1

  公开（公告）日：2007-12-21

  [EN] In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds of formula (I) as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.
  [FR] Dans de nombreux modes de réalisation, la présente invention concerne une nouvelle classe de composés d'imidazopyrazine représentés par la formule (I), utilisés en tant qu'inhibiteurs de kinases protéiques et/ou de kinases point de contrôle, des procédés de préparation de tels composés, des compositions pharmaceutiques contenant un ou plusieurs desdits composés, des procédés de préparation de formulations pharmaceutiques contenant un ou plusieurs desdits composés, et des méthodes de traitement, de prévention, d'inhibition, ou d'atténuation d'une ou plusieurs maladies associées aux kinases protéiques ou aux kinases point de contrôle à l'aide desdits composés ou desdites compositions pharmaceutiques.
• [EN] IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS<br/>[FR] IMIDAZOPYRAZINES EN TANT QU'INHIBITEURS DE PROTÉINES KINASES
  申请人：SCHERING CORP

  公开号：WO2010088368A2

  公开（公告）日：2010-08-05

  In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.