7,7-dimethyl-7,8-dihydrobenzo[3,4]oxonino[6,7-b]quinoxaline-5,9-dione | 1155730-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7,7-dimethyl-7,8-dihydrobenzo[3,4]oxonino[6,7-b]quinoxaline-5,9-dione
• 英文别名: (7,7-Dimethyl-7,8-dihydrobenzo[3,4]oxonino[6,7-b]quinoxaline-5,9-dione)；10,10-dimethyl-9-oxa-14,21-diazatetracyclo[11.8.0.02,7.015,20]henicosa-1(21),2,4,6,13,15,17,19-octaene-8,12-dione
• CAS: 1155730-32-7
• 化学式: C₂₀H₁₆N₂O₃
• 分子量: 332.359
• InChiKey: FKVHNIDETFYCSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-1,2-dihydro-benzo[a]furo[2,3-c]phenazine 在 双氧水 、 乙酸酐 作用下， 以 氯仿 、 水 为溶剂， 反应 24.0h， 以70%的产率得到7,7-dimethyl-7,8-dihydrobenzo[3,4]oxonino[6,7-b]quinoxaline-5,9-dione
  参考文献：
  名称：

  A macrolactone from benzo[a]phenazine with potent activity against Mycobacterium tuberculosis

  摘要：

  We report here an alternative to the MCPBA or ozonolysis-based oxidation methods of quinoxaline-featuring compounds prepared from beta-lapachones. The use of peracetic acid allowed a simple preparation of the corresponding macrolactones by cleavage of the ring system. These lactones were evaluated for their antimycobacterial potential and compound 4 turned out to have an MIC of 0.62 mu g per mL on Mycocabteriumtuberculosis H37Rv. These results justify further research into its value as a potential lead for an original treatment of tuberculosis. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.06.014