tris(2-(N-methylamino)ethyl)methane | 1332869-44-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tris(2-(N-methylamino)ethyl)methane
• 英文别名: N,N'-dimethyl-3-[2-(methylamino)ethyl]pentane-1,5-diamine
• CAS: 1332869-44-9
• 化学式: C₁₀H₂₅N₃
• 分子量: 187.329
• InChiKey: VJDOYYHQXPWNFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  acetic acid 2-acetoxy-2-[3-(allyl-methyl-carbamoyl)-5-chlorocarbonyl-2,4,6-triiodo-phenylcarbamoyl]-ethyl ester 、 tris(2-(N-methylamino)ethyl)methane 在 三乙胺 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 生成
  参考文献：
  名称：

  The synthesis and evaluation of trimeric X-ray contrast agents

  摘要：

  Novel trimeric iodinated contrast agents with low osmolality have been prepared and evaluated with the aim of improving the already good safety profile of such agents. While the aim of low osmolality was achieved, the viscosity of the trimeric agents was found to be generally higher than current dimeric agents in clinical use. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.010

文献信息

• BORATE-BASED BASE GENERATOR, AND BASE-REACTIVE COMPOSITION COMPRISING SUCH BASE GENERATOR
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：US20160340374A1

  公开（公告）日：2016-11-24

  An object of the present invention is to provide a compound which is capable of attaining a composition having high storage stability without reacting with a base-reactive compound, even in the case of storage for a long period of time in a mixed state with the base-reactive compound, such as an epoxy-based compound, as well as capable of generating a strong base (guanidines, biguanides, phosphazenes or phosphoniums) by irradiation of light (active energy rays) or heating; a base generator comprising the compound; and a base-reactive composition comprising the base generator and the base-reactive compound. The present invention relates to the compound represented by the general formula (A); the base generator comprising the compound; and the base-reactive composition comprising the base generator and the base-reactive compound. (wherein R 1 represents an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; an alkenyl group; a 2-furylethynyl group; a 2-thiophenylethynyl group; or a 2,6-dithianyl group; R 2 to R 4 each independently represent an alkyl group; an arylalkynyl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; the aryl group which may be substituted with a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group; a furanyl group; a thienyl group; or an N-alkyl-substituted pyrrolyl group; Z + represents an ammonium cation having a guanidinium group, a biguanidium group or a phosphazenium group, or a phosphonium cation.)

  本发明的目的是提供一种化合物，能够在与碱反应性化合物混合状态长时间存储的情况下，仍能获得具有高储存稳定性的组合物，而不与碱反应性化合物发生反应，同时还能通过光照（活性能量射线）或加热产生强碱（胍胺、双胍胺、磷氮烷或磷銨）；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。本发明涉及由通式（A）表示的化合物；包括该化合物的碱发生器；以及包括该碱发生器和碱反应性化合物的碱反应性组合物。（其中R1代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；烯基；2-呋喃基炔基；2-噻吩基炔基；或2,6-二硫基基；R2到R4各自独立地代表烷基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基炔基；可能被卤素原子、烷基、烷氧基或烷硫基取代的芳基；呋喃基；噻吩基；或N-烷基取代的吡咯基；Z+代表具有胍胺基团、双胍胺基团或磷氮烷基团的铵阳离子，或磷銨阳离子。）
• PROTECTED FLUORESCENT REAGENT COMPOUNDS
  申请人：Pacific Biosciences of California, Inc.

  公开号：US20150050659A1

  公开（公告）日：2015-02-19

  Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

  提供了受保护的荧光试剂化合物及其合成方法。这些化合物在各种基于荧光的分析方法中很有用，包括在高密度下对大量高度多重光学反应进行分析，例如单分子实时核酸测序反应。这些化合物包含荧光染料元素，使得这些化合物能够在理想波长下以高灵敏度被检测到，结合元素，使得这些化合物能够被特异性地识别目标生物分子，并且保护盾元素，减少荧光染料元素与结合的目标生物分子之间的不良接触，从而减少荧光染料元素对结合的目标生物分子造成的光损伤。
• Borate-based base generator, and base-reactive composition comprising such base generator
  申请人：FUJIFILM Wako Pure Chemical Corporation

  公开号：US10100070B2

  公开（公告）日：2018-10-16

  A compound capable of providing a composition having high storage stability without reacting with a base-reactive compound, even when stored in a mixed state with the base-reactive compound, as well as capable of generating a strong base by irradiation of light (active energy rays) or heating. A base generator comprises the compound and a base-reactive composition comprises the base generator and the base-reactive compound. The compound is represented by the general formula (A).

  一种化合物，能够提供一种具有高储存稳定性的组合物，即使在与碱反应化合物混合储存的状态下，也不会与碱反应化合物发生反应，并且能够通过光（活性能量射线）照射或加热生成强碱。碱发生器由该化合物组成，碱反应组合物由碱发生器和碱反应化合物组成。该化合物由通式 (A) 表示。
• US9957291B2
  申请人：——

  公开号：US9957291B2

  公开（公告）日：2018-05-01