卡培他滨杂质 | 71609-08-0

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 中文名称: 卡培他滨杂质
• 英文名称: 4-amino-1-(β-D-5-deoxy-arabinofuranosyl)-5-fluoro-1H-pyrimidin-2-one
• 英文别名: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidin-2-one
• CAS: 71609-08-0
• 化学式: C₉H₁₂FN₃O₄
• 分子量: 245.21
• InChiKey: YSNABXSEHNLERR-YQHTUYAKSA-N

物化性质

• 沸点：
  437.9±55.0 °C(Predicted)
• 密度：
  1.84±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Process for the preparation of capecitabine
  申请人：MacDonald Peter Lindsay

  公开号：US20090209754A1

  公开（公告）日：2009-08-20

  The present application relates to an improved process for the preparation of capecitabine.

  本申请涉及一种改进的卡培他滨制备过程。
• HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS
  申请人：Yu, Chongxi

  公开号：EP2370406A1

  公开（公告）日：2011-10-05
• [EN] HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS<br/>[FR] COMPOSITIONS À PÉNÉTRATION ÉLEVÉE ET LEURS APPLICATIONS
  申请人：YU CHONGXI

  公开号：WO2010065936A1

  公开（公告）日：2010-06-10

  High penetration compositions (HPC) of a parent compound, which are capable of crossing biological barriers with high penetration efficiency. The HPCs are capable of being converted to parent drugs or parent drug-related compounds such as metabolites after crossing one or more biological barriers and thus can render treatments for the conditions that the parent drugs or parent drug-related compounds can. Additionally, the HPCs are capable of reaching areas that their parent drugs or parent drug-related compounds may not be able to access or to render a sufficient concentration at the target areas HPCs of NSAIA, for example, have demonstrated indications such as treating hair loss. A HPC can be administered to a subject through various administration routes, e. g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.