(4R)-5,5-dimethyl-8'-pyrazin-2-ylspiro[1,3-oxazole-4,3'-2,4-dihydro-1H-naphthalene]-2-amine | 1221164-08-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (4R)-5,5-dimethyl-8'-pyrazin-2-ylspiro[1,3-oxazole-4,3'-2,4-dihydro-1H-naphthalene]-2-amine
• CAS: 1221164-08-4
• 化学式: C₁₈H₂₀N₄O
• 分子量: 308.383
• InChiKey: MXHNYDGAYGVZCJ-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  73.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] BIARYL SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS<br/>[FR] ANALOGUES DE BIARYL-SPIROAMINOOXAZOLINE EN TANT QUE MODULATEURS DE RÉCEPTEUR ADRÉNERGIQUE ALPHA2C
  申请人：SCHERING CORP

  公开号：WO2010042473A1

  公开（公告）日：2010-04-15

  In its many embodiments, the present invention provides a novel class of biaryi spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

  本发明的多种实施例提供了一类新型的双芳基螺氨氧杂萘类衍生物，作为α2C肾上腺素受体激动剂的调节剂，提供了制备这类化合物的方法，包含一个或多个这类化合物的药物组合物，制备包含一个或多个这类化合物的药物制剂的方法，以及使用这类化合物或药物组合物治疗、预防、抑制或改善与α2C肾上腺素受体相关的一个或多个条件的方法。
• BIARYL-SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA 2C ADRENERGIC RECEPTOR MODULATORS
  申请人：McCormick Kevin D.

  公开号：US20110251207A1

  公开（公告）日：2011-10-13

  In its many embodiments, the present invention provides a novel class of biaryi spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了一种新型的双芳基螺环氨氧嗪类似物，作为α2C肾上腺素受体激动剂的调节剂，制备这种化合物的方法，含有一种或多种这种化合物的药物组合物，制备包含一种或多种这种化合物的制剂的方法，以及使用这种化合物或药物组合物治疗、预防、抑制或改善与α2C肾上腺素受体相关的一种或多种疾病的方法。
• BIARYL SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20130045914A1

  公开（公告）日：2013-02-21

  In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了一种新型的双芳基螺环氨氧嗪类似物，作为α2C肾上腺素受体激动剂的调节剂，制备这种化合物的方法，含有一种或多种这种化合物的药物组合物，制备包含一种或多种这种化合物的药物制剂的方法，以及使用这种化合物或药物组合物治疗、预防、抑制或改善与α2C肾上腺素受体相关的一种或多种疾病的方法。
• BIARYL-SPIROAMINOOXZAOLINE ANALOGUES AS ALPHA 2C ADRENERGIC RECEPTOR MODULATORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20130225582A1

  公开（公告）日：2013-08-29

  In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了一种新型的双芳基螺环氨氧唑啉类似物，作为α2C肾上腺素能受体激动剂的调节剂，制备这种化合物的方法，包含一种或多种这种化合物的制药组合物，制备包含一种或多种这种化合物的制药配方的方法，以及使用这种化合物或制药组合物治疗、预防、抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。
• US8324213B2
  申请人：——

  公开号：US8324213B2

  公开（公告）日：2012-12-04