2,2-Dimethyl-6-phenylsulfanyl-2H-chromene | 185316-61-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2,2-Dimethyl-6-phenylsulfanyl-2H-chromene
• 英文别名: 2,2-dimethyl-6-phenylthio-2H-1-benzopyran；2,2-dimethyl-6-phenylsulfanylchromene
• CAS: 185316-61-4
• 化学式: C₁₇H₁₆OS
• 分子量: 268.379
• InChiKey: ZYDGZMQYPKPDCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-6-phenylsulfanyl-2H-chromene 在 间氯过氧苯甲酸 作用下， 生成 2,2-dimethyl-6-phenyl-sulfonyl-2H-chromene
  参考文献：
  名称：

  A convenient Synthesis of 6-Substituted-2,2-Dimethyl-2H-1-Benzopyrans

  摘要：

  Various 2,2-dimethyl-6-functional-2H-1-benzopyrans were prepared via a halogen-metal exchange reaction followed by treatment with electrophiles. These 6-functionalized chromenes are important synthetic intermediates for preparation of benzopyran-based potassium channel openers.

  DOI：

  10.1080/00397919608004664
• 作为产物：
  描述：

  1-溴-4-[(1,1-二甲基-2-丙炔基)氧基]苯 在 正丁基锂 、 N,N-二乙基苯胺 作用下， 反应 3.0h， 生成 2,2-Dimethyl-6-phenylsulfanyl-2H-chromene
  参考文献：
  名称：

  A convenient Synthesis of 6-Substituted-2,2-Dimethyl-2H-1-Benzopyrans

  摘要：

  Various 2,2-dimethyl-6-functional-2H-1-benzopyrans were prepared via a halogen-metal exchange reaction followed by treatment with electrophiles. These 6-functionalized chromenes are important synthetic intermediates for preparation of benzopyran-based potassium channel openers.

  DOI：

  10.1080/00397919608004664

文献信息

• NOVEL BENZOPYRAN DERIVATIVES AS POTASSIUM CHANNEL OPENERS
  申请人：Zhang Xuqing

  公开号：US20070049556A1

  公开（公告）日：2007-03-01

  The present invention is directed to novel benzopyran derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.

  本发明涉及新型苯并吡喃衍生物，含有它们的药物组合物以及它们在治疗与钾通道相关的疾病中的应用。
• Benzopyran derivatives as potassium channel openers
  申请人：Janssen Pharmaceutica NV

  公开号：US07812183B2

  公开（公告）日：2010-10-12

  The present invention is directed to novel benzopyran derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.

  本发明涉及新型苯并吡喃衍生物，包含它们的药物组合物以及它们在治疗与钾通道相关的疾病中的应用。
• BENZOPYRAN AND PYRANOPYRIDINE DERIVATIVES AS POTASSIUM CHANNEL OPENERS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP1940516A2

  公开（公告）日：2008-07-09
• US7812183B2
  申请人：——

  公开号：US7812183B2

  公开（公告）日：2010-10-12
• US7838553B2
  申请人：——

  公开号：US7838553B2

  公开（公告）日：2010-11-23