N,N'-bis[(5-nitrofuran-2-yl)methylideneamino]butanediamide | 94783-48-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: N,N'-bis[(5-nitrofuran-2-yl)methylideneamino]butanediamide
• CAS: 94783-48-9
• 化学式: C₁₄H₁₂N₆O₈
• 分子量: 392.285
• InChiKey: KRCNTWLEHFMAFQ-UHFFFAOYSA-N

物化性质

• 密度：
  1?+-.0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.07
• 重原子数：
  28.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  195.48
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  N,N'-bis[(5-nitrofuran-2-yl)methylideneamino]butanediamide 在 溴 、 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以74%的产率得到2-(5-Nitrofuran-2-yl)-5-[2-[5-(5-nitrofuran-2-yl)-1,3,4-oxadiazol-2-yl]ethyl]-1,3,4-oxadiazole
  参考文献：
  名称：

  Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes

  摘要：

  The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 mu g/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00154-9
• 作为产物：
  描述：

  5-硝基糠醛 、 丁二酸二酰肼 在 硫酸 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 以82%的产率得到N,N'-bis[(5-nitrofuran-2-yl)methylideneamino]butanediamide
  参考文献：
  名称：

  Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes

  摘要：

  The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 mu g/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00154-9

文献信息

• Synthesis and antibacterial studies of a new series of 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes
  作者：B.Shivararna Holla、Richard Gonsalves、Shalini Shenoy

  DOI：10.1016/s0223-5234(00)00154-9

  日期：2000.2

  The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 mu g/mL concentration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.