cis-5'-O-(4,4-dimethyl-6-phenyl-1,2,3-dioxa-2-oxo-phosphorin-2-yl)-2'-C-methyl-2-amino-7-deaza-adenosine | 926654-56-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: cis-5'-O-(4,4-dimethyl-6-phenyl-1,2,3-dioxa-2-oxo-phosphorin-2-yl)-2'-C-methyl-2-amino-7-deaza-adenosine
• 英文别名: (2R,3R,4R,5R)-2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(4,4-dimethyl-2-oxo-6-phenyl-1,3,2lambda5-dioxaphosphinan-2-yl)oxymethyl]-3-methyloxolane-3,4-diol；(2R,3R,4R,5R)-2-(2,4-diaminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(4,4-dimethyl-2-oxo-6-phenyl-1,3,2λ5-dioxaphosphinan-2-yl)oxymethyl]-3-methyloxolane-3,4-diol
• CAS: 926654-56-0
• 化学式: C₂₃H₃₀N₅O₇P
• 分子量: 519.494
• InChiKey: OEKMPBAJCNURAU-WFZHHVDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  177
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Novel 2'-c-methyl and 4'c-methyl nucleoside derivatives
  申请人：Erion Mark D.

  公开号：US20090118223A1

  公开（公告）日：2009-05-07

  Novel 2′-C-methyl nucleoside 5′-monophosphate and 4′-C-methyl nucleoside 5′-monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described.