(24R)-24-methyl-5α-cholestan-3β-yl acetate | 55903-58-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (24R)-24-methyl-5α-cholestan-3β-yl acetate
• 英文别名: 24-methyl-5α-cholestan-3β-yl acetate；ergostanyl acetate；campestanyl acetate；(10S)-3c-Acetoxy-10r.13c-dimethyl-17c-((1R:4R)-1.4.5-trimethyl-hexyl)-(5tH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；Essigsaeure-(5α.24β_FH-ergostanyl-(3β)-ester)；5α.24β_FH-Ergostanyl-(3β)-acetat；Campestanol acetate；[(3S,5S,8R,9S,10S,13R,14S,17R)-17-[(2R,5R)-5,6-dimethylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• CAS: 55903-58-7
• 化学式: C₃₀H₅₂O₂
• 分子量: 444.742
• InChiKey: CVXQLNHSKSSFSQ-RSRWTXHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (24R)-24-methyl-5α-cholestan-3β-yl acetate 在 2,6-二氯吡啶N-氧化物 、 (carbonyl)(5,10,15,20-tetramesitylporphyrinato)ruthenium(II) 、 氢溴酸 作用下， 以 苯 为溶剂， 反应 48.0h， 以17%的产率得到(24S)-24-hydroxy-24-methyl-5α-cholestan-3β-yl acetate
  参考文献：
  名称：

  立体选择性合成和24个烷基氧甾醇的C-24个对映异构体的NMR表征

  摘要：

  两对C-24差向异构体（24 - [R ）- /（24小号）-24羟基-24-甲基-5- α -胆甾3 β基乙酸酯和（24 - [R ） - /（24小号）-25-羟基-24-甲基-5- α -胆甾3 β基乙酸酯以及一些相关的24乙基氧固醇类似物立体选择性地直接从各自的父由远程合成24烷基固醇ö -insertion与2,6-反应催化量的（5,10,15,20-四甲叉基卟啉）钌（II）羰基络合物[Ru（TMP）CO]和HBr存在下的二氯吡啶N-氧化物（DCP）。1 H‐和13解释了用来区分两个差向异构对的C-NMR信号。发现C-24上的C-24烷基氧固醇是由C 5 D 5 N引起的芳族溶剂诱导的位移（ASIS）有效表征的，特别是对于取代的胆甾烷侧链中13 C共振的差异。在iso中区分端子26- / 27-CH 3的1 H和13 C信号分配的方法还结合了首选的构象分析和HMQC和HMBC技术

  DOI：

  10.1007/s11745-012-3739-1
• 作为产物：
  描述：

  5α.24β_FH-ergosten-(22t)-yl-(3β)-acetate 在 乙酸乙酯 、 铂 作用下， 生成 (24R)-24-methyl-5α-cholestan-3β-yl acetate
  参考文献：
  名称：

  对水产品研究的贡献；海绵甾醇。

  摘要：

  DOI：

  10.1021/jo01182a013

文献信息

• Roadside Particulate Air Pollution in Bangkok
  作者：Wanida Jinsart、Kenji Tamura、Samarnchai Loetkamonwit、Sarawut Thepanondh、Kanae Karita、Eiji Yano

  DOI：10.1080/10473289.2002.10470845

  日期：2002.9

  Airborne fine particles of PM2.5-10 and PM2.5 in Bangkok, Nonthaburi, and Ayutthaya were measured from December 22, 1998, to March 26, 1999, and from November 30, 1999, to December 2, 1999. Almost all the PM10 values in the high-polluted (H) area exceeded the Thailand National Ambient Air Quality Standards (NAAQS) of 120 mug/m(3). The low-polluted (L) area showed low PM10 (34-74 mug/m(3) in the daytime and 54-89 mug/m(3) at night). PM2.5 in the H area varied between 82 and 143 mug/m(3) in the daytime and between 45 and 146 mug/m(3) at night. In the L area, PM2.5 was quite low both day and night and varied between 24 and 54 mug/m(3), lower than the U.S. Environmental Protection Agency (EPA) standard (65 mug/m(3)). The personal exposure results showed a significantly higher proportion of PM2.5 to PM10 in the H area than in the L area (H = 0.80 +/- 0.08 and L = 0.65 +/- 0.04).Roadside PM10 was measured simultaneously with the Thailand Pollution Control Department (PCD) monitoring station at the same site and at the intersections where police work. The result from dual simultaneous measurements of PM10 showed a good correlation (correlation coefficient: r = 0.93); however, PM levels near the roadside at the intersections were higher than the concentrations at the monitoring station. The relationship between ambient PM level and actual personal exposures was examined. Correlation coefficients between the general ambient outdoors and personal exposure levels were 0.92 for both PM2.5 and PM10.Bangkok air quality data for 1997-2000, including 24-hr average PM10, NO2, SO2, and O-3 from eight PCD monitoring stations, were analyzed and validated. The annual arithmetic mean PM10 of the PCD data at the roadside monitoring stations for the last 3 years decreased from 130 to 73 mug/m(3), whereas the corresponding levels at the general monitoring stations decreased from 90 to 49 mug/m(3). The proportion of days when the level of the 24-hr average PM10 exceeded the NAAQS was between 13 and 26% at roadside stations. PCD data showed PM10 was well correlated with NO2 but not with SO2, suggesting that automobile exhaust is the main source of the particulate air pollution. The results obtained from the simultaneous measurement of PM2.5 and PM10 indicate the potential environmental health hazard of fine particles. In conclusion, Bangkok traffic police were exposed to high levels of automobile-derived particulate air pollution.
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  作者：Erhard Fernholz、William L. Ruigh

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