1,1-dimethylpropyl N-[3-(aminomethyl)oxetan-3-yl]carbamate | 1802048-95-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 1,1-dimethylpropyl N-[3-(aminomethyl)oxetan-3-yl]carbamate
• 英文别名: Tert-pentyl (3-(aminomethyl)oxetan-3-yl)carbamate；2-methylbutan-2-yl N-[3-(aminomethyl)oxetan-3-yl]carbamate
• CAS: 1802048-95-8
• 化学式: C₁₀H₂₀N₂O₃
• 分子量: 216.28
• InChiKey: KBNDCKJCMHZJEH-UHFFFAOYSA-N

物化性质

• 沸点：
  330.8±35.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PROCESS FOR THE PREPARATION OF N-[(3-AMINOOXETAN-3-YL)METHYL]-2-(1,1-DIOXO-3,5-DIHYDRO-1,4-BENZOTHIAZEPIN-4-YL)-6-METHYL-QUINAZOLIN-4-AMINE
  申请人：Hoffmann-La Roche Inc.

  公开号：US20160326160A1

  公开（公告）日：2016-11-10

  The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

  本发明涉及一种用于制备式(I)化合物的新工艺，以及其药学上可接受的酸盐，该化合物对哺乳动物或人类呼吸道合胞病毒（RSV）感染的预防和治疗具有用处。
• [EN] PROCESS FOR THE PREPARATION OF N-[(3-AMINOOXETAN-3-YL)METHYL]-2-(1,1-DIOXO-3,5-DIHYDRO-1,4-BENZOTHIAZEPIN-4-YL)-6-METHYL-QUINAZOLIN-4-AMINE<br/>[FR] PROCEDE POUR LA PREPARATION DE N-[(3-AMINOOXETAN-3-YL)METHYL]-2-(L,L-DIOXO-3,5-DIHYDRO- L,4-BENZOTHIAZEPIN-4-YL)-6-METHYL-QUINAZOLIN-4-AMINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015110446A1

  公开（公告）日：2015-07-30

  The present invention relates to a novel process for the preparation of a compound of the formula (I) and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

  本发明涉及一种新颖的工艺，用于制备公式（I）的化合物及其药用可接受的酸性加成盐，该化合物用于预防或治疗哺乳动物或人类的呼吸道合胞病毒（RSV）感染。
• PROCESS FOR THE PREPARATION OF N-[3-(AMINOMETHYL)OXETAN-3-YL]CARBAMATE INTERMEDIATES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3248969A1

  公开（公告）日：2017-11-29

  The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

  本发明涉及一种制备式 (I) 化合物的新工艺： 及其药学上可接受的酸加成盐，可用于预防和治疗哺乳动物或人类的呼吸道合胞病毒（RSV）感染。
• Process for the preparation of N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine
  申请人：Hoffmann-La Roche Inc.

  公开号：US10005770B2

  公开（公告）日：2018-06-26

  The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

  本发明涉及一种制备式 (I) 化合物的新工艺： 及其药学上可接受的酸加成盐，可用于预防和治疗哺乳动物或人类的呼吸道合胞病毒（RSV）感染。
• Process for the preparation of N-[(3-aminooxetan-3-yl) methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine
  申请人：Hoffmann-La Roche Inc.

  公开号：US10253022B2

  公开（公告）日：2019-04-09

  The present invention relates to a novel process for the preparation of a compound of the formula (I): and pharmaceutically acceptable acid addition salts thereof, which is useful for prophylaxis and treatment of respiratory syncytial virus (RSV) infection in mammal or human being.

  本发明涉及一种制备式 (I) 化合物的新工艺： 及其药学上可接受的酸加成盐，可用于预防和治疗哺乳动物或人类的呼吸道合胞病毒（RSV）感染。