(2Z,2'Z)-N,N'-(1,3-phenylenebis(methylene))bis(3-([2,2'-bithiophen]-5-yl)-2-cyanoacrylamide) | 1567834-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 双噻吩和低聚噻吩
• 英文名称: (2Z,2'Z)-N,N'-(1,3-phenylenebis(methylene))bis(3-([2,2'-bithiophen]-5-yl)-2-cyanoacrylamide)
• 英文别名: (Z)-2-cyano-N-[[3-[[[(Z)-2-cyano-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enoyl]amino]methyl]phenyl]methyl]-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enamide
• CAS: 1567834-58-5
• 化学式: C₃₂H₂₂N₄O₂S₄
• 分子量: 622.816
• InChiKey: UYXZATVMXIJTHG-MPKYGIEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  219
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,2-联噻吩-5-乙醛 、 2-cyano-N-{3-[(2-cyanoacetylamino)methyl]benzyl}acetamide 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 (2Z,2'Z)-N,N'-(1,3-phenylenebis(methylene))bis(3-([2,2'-bithiophen]-5-yl)-2-cyanoacrylamide)
  参考文献：
  名称：

  Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)

  摘要：

  A series of degrasyn-like symmetrical compounds have been designed, synthesized, and screened against B cell malignancy (multiple myeloma, mantle cell lymphoma) cell lines. The lead compounds T5165804 and CP2005 showed higher nanomolar potency against these tumor cells in comparison to degrasyn and inhibited Usp9x activity in vitro and in intact cells. These observations suggest that this new class of compounds holds promise as cancer therapeutic agents. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2013.12.048

文献信息

• Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
  申请人：Emory University

  公开号：EP2364702A2

  公开（公告）日：2011-09-14

  A composition is provided which comprises one or more Kinase inhibitors for use for preventing or treating a pathogenic infection caused by a broad array of pathogens in a patient in need thereof.

  本发明提供了一种组合物，其中包含一种或多种激酶抑制剂，用于预防或治疗由多种病原体引起的病原体感染。
• Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof
  申请人：Kalman Daniel

  公开号：US20100249122A1

  公开（公告）日：2010-09-30

  The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
• KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF
  申请人：Kalman Daniel

  公开号：US20120302565A1

  公开（公告）日：2012-11-29

  The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
• US8268809B2
  申请人：——

  公开号：US8268809B2

  公开（公告）日：2012-09-18
• [EN] KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF<br/>[FR] INHIBITEURS DE KINASE POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE INFECTION PATHOGÈNE ET PROCÉDÉ D'UTILISATION DE CEUX-CI
  申请人：UNIV EMORY

  公开号：WO2008079460A2

  公开（公告）日：2008-07-03

  [EN] The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.
  [FR] La présente invention propose des compositions et des procédés d'utilisation de celles-ci pour prévenir et/ou traiter une infection pathogène. La présente invention propose notamment l'utilisation d'inhibiteurs de kinase pour inhiber les kinases qui impliquent des interactions de cellules porteuses d'agent pathogène qui sont associées à des infections pathogènes ou qui les provoquent, pour ainsi prévenir et/ou traiter efficacement les infections pathogènes avec une probabilité bien moins importante d'engendrer une résistance en comparaison avec les antibiotiques et les antiviraux classiques. La présente invention propose également l'utilisation d'inhibiteurs de kinase pour le traitement d'infections pathogènes aiguës pendant une courte période pour éviter des toxicités susceptibles d'être provoquées par une utilisation à long terme de ces inhibiteurs de kinase.