4-(morpholinomethyl)thieno[3,4-d]-1,3-dithiole-2-thione | 1173183-47-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(morpholinomethyl)thieno[3,4-d]-1,3-dithiole-2-thione
• 英文别名: 4-(Morpholin-4-ylmethyl)thieno[3,4-d][1,3]dithiole-2-thione；4-(morpholin-4-ylmethyl)thieno[3,4-d][1,3]dithiole-2-thione
• CAS: 1173183-47-5
• 化学式: C₁₀H₁₁NOS₄
• 分子量: 289.467
• InChiKey: KZUSPYHJZGGMPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  123
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 4-(morpholinomethyl)thieno[3,4-d]-1,3-dithiole-2-thione 、 吗啡啉盐酸盐 、 溶剂黄146 反应 24.0h， 以35%的产率得到4,6-bis(morpholinomethyl)thieno[3,4-d]-1,3-dithiole-2-thione
  参考文献：
  名称：

  Mannich reactions of annulated thiophene derivatives

  摘要：

  Aminoalkylation reactions were applied to two annulated thiophene derivatives to successfully prepare mono- and bis-substituted Mannich bases. Compounds were characterized by NMR, FT-IR, and HRMS. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.222
• 作为产物：
  描述：

  聚合甲醛 、 thieno[3,4-d]-1,3-dithiol-2-thione 、 吗啡啉盐酸盐 以 溶剂黄146 为溶剂， 反应 24.0h， 以81%的产率得到4-(morpholinomethyl)thieno[3,4-d]-1,3-dithiole-2-thione
  参考文献：
  名称：

  Mannich reactions of annulated thiophene derivatives

  摘要：

  Aminoalkylation reactions were applied to two annulated thiophene derivatives to successfully prepare mono- and bis-substituted Mannich bases. Compounds were characterized by NMR, FT-IR, and HRMS. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.222

文献信息

• Mannich reactions of annulated thiophene derivatives
  作者：Xin Chen、Ronald L. Elsenbaumer

  DOI：10.1016/j.tetlet.2009.03.222

  日期：2009.7

  Aminoalkylation reactions were applied to two annulated thiophene derivatives to successfully prepare mono- and bis-substituted Mannich bases. Compounds were characterized by NMR, FT-IR, and HRMS. (C) 2009 Elsevier Ltd. All rights reserved.